Author(s)

Wael Al-Aghawani, Bassel Hussein

Faculty of Pharmacy, Al-Sham Private University (ASPU), Damascus, Syria.

Background: Convolvulus arvensis L. (Convolvulaceae) possess several biological properties and has been used in the treatment of hepatic obstructions. The present study aimed to evaluate the relaxant effects of the alcoholic extract of C. arvensis on both spontaneous and phenylephrine-induced contraction of isolated rat portal vein. Materials and Methods: First, the effect of the extracts was examined on spontaneous rhythmic contraction of longitudinal-cut portal strips, the extract was added cumulatively to tissues’ baths. In another set of experiments, two groups of portal strips were used, one group was intact endothelium and the other was without endothelium. They were contracted by phenylephrine and then the extract was added similarly as previously. The changes in contraction were measured and recorded by isolated organ system (I.O.S). Results: The previous extract exhibited profound relaxant effect on both spontaneous and phenylephrine-induced contraction of portal preparations. The effect of the extract was the same in both intact and denuded endothelium portal strips. Conclusion: The extract of Convolvulus arvensis has obvious relaxing effects on both rhythmic and phenylephrine-induced contraction with no role for endothelium. Further studies are encouraged to illustrate the mechanisms and to isolate the related active compound(s).

Convolvulus arvensis, Portal Vein, Phenylephrine, Spontaneous Contraction

Al-Aghawani, W. and Hussein, B. (2022) Study the Effect of Convolvulus arvensis on the Contraction of Isolated Vascular Smooth Muscle Fibers Portal Vein. Open Access Library Journal, 9, 1-8. doi: 10.4236/oalib.1108407.