Author(s)

Qiangcai Mai^1*, Lihua Qan^2,3#, Guosheng Su^2#†, Miaoling Liang^1*, Xiaoye Su^3,4, Yu Gan¹, Qinglu Li¹, Can Long¹, Huayan Zhu¹, Qiaocui Jiang¹, Yanling Zheng¹, Jieli He¹, Tianwu Liang¹, Jing Li¹, Buqing Su⁵

¹Department of Gastroenterology/Laboratory, Guigang Orthopedic Hospital of Integrated Traditional Chinese and Western Medicine, Guigang, China.
²Department of Internal Medicine/Laboratory Department of the People’s Hospital of Guangxi ASEAN Economic and Technological Development Zone, Nanning Tenth People’s Hospital, Nanning, China.
³Department of Nursing, Graduate School, Eternal University of the Philippines, Las Pinas, Philippines.
⁴Department of Critical Medicine, Fuzhou Second People’s Hospital, Fuzhou, China.
⁵Nursing Department of Liaoning Hospital Vocational College, Shenyang, China.

Objective: To understand the clinical value of combined detection of cholyglycine CG and TBA in differential diagnosis of hepatobiliary diseases. Methods: Serum samples from 50 healthy people were collected as healthy control group. According to the latest disease diagnosis and treatment plan, 58 cases of HBV asymptomatic carrier group, 17 cases of viral hepatitis group, 49 cases of cirrhosis group, 50 cases of primary liver cancer group and 50 cases of other hepatobiliary diseases groups were collected respectively. The concentration levels of cholyglycine and total bile acid in each group were detected, and the differences among each group were compared. Results: By statistical analysis, serum CG concentration in viral hepatitis group, cirrhosis group, primary liver cancer group and other hepatobiliary diseases group was significantly higher than that in asymptomatic HEPATITIS B carriers and healthy control group, the differences were statistically significant (p < 0.05). While, the serum CG concentration of asymptomatic hepatitis B virus carrier group was similar to that of healthy control group, the difference was not statistically significant (p > 0.05). There was no significant difference in CG concentration among viral hepatitis group, liver cirrhosis group, primary liver cancer group and other hepatobiliary diseases group (p > 0.05). The serum TBA levels of asymptomatic carriers, viral hepatitis group, cirrhosis group, primary liver cancer group and other hepatobiliary system diseases group were significantly higher than those of healthy control group, the difference was statistically significant, p < 0.05. There was no significant difference in TBA concentration among the asymptomatic carriers of hepatitis B virus, viral hepatitis group, liver cirrhosis group, primary liver cancer group and other hepatobiliary system disease groups, all p > 0.05. Conclusion: Serum CG expression can not only detect liver lesions, but also distinguish different liver lesions. The positive rate of CG combined with TBA detection in patients with hepatobiliary diseases is significantly higher than that of single CG index detection. CG combined with TBA detection can significantly improve the sensitivity and accuracy of the diagnosis of hepatobiliary diseases, which is worthy of popularization and application.

Cholyglycine, Total Bile Acid, Hepatobiliary Diseases, Primary Liver Cancer, The Differential Diagnosis

Mai, Q. , Qan, L. , Su, G. , Liang, M. , Su, X. , Gan, Y. , Li, Q. , Long, C. , Zhu, H. , Jiang, Q. , Zheng, Y. , He, J. , Liang, T. , Li, J. and Su, B. (2022) Clinical Application Value of Combined Detection of CG and TBA in Differential Diagnosis of Hepatobiliary System Diseases. Natural Science, 14, 71-77. doi: 10.4236/ns.2022.142008.