Author(s)

Mohamed Sanhoury^1,2*, Gaetano Fassini¹, Salvatore Pala¹, Massimo Moltrasio¹, Fabrizio Tundo¹, Stefania Riva¹, Antonio Dello Russo¹, Michela Casella¹, Claudio Tondo¹

¹Cardiac Arrhythmia Research Centre, Department of Cardiovascular Sciences, University of Milan, Centro Cardiologico Monzino, IRCCS, Milan, Italy.
²Electrophysiology Unit, Department of Cardiology and Angiology, University of Alexandria, Alexandria, Egypt.

Background: Pulmonary vein isolation by means of cryoballoon is a well-established way of treatment of atrial fibrillation. The aim of the study was to compare the acute cryoballoon biophysical parameters attained during energy applications to the individual pulmonary vein during sinus rhythm versus atrial fibrillation. Methods: 100 Patients who underwent their first-time PVI using second-generation cryoballoon for symptomatic and drug-refractory AF, between the beginning of March to end of August 2016, were initially screened. 61 patients with paroxysmal AF were included in the present study. 39 patients with persistent AF were excluded. No pre-procedural anatomical imaging was reported. Results: A total of 61 patients (male 80%, age 59.3 ± 13.4 years) were included in the present analysis. A total of 243 pulmonary veins were isolated with an average of 1.87 ± 1.14 cryo energy applications per individual vein. During cryo application, there were no significant differences between applications delivered during sinus rhythm or ongoing AF in the rate of temperature drop at 5 and 30 s, rate of warming at 5 s after freezing stop or achieved balloon nadir temperature. The same also was observed for both the balloon cooling rate and warming times. Conclusions: The present analysis shows no impact of the patient baseline rhythm at the time of energy application upon the acute balloon biophysical parameters in patients with normal sinus rhythm and those with ongoing atrial fibrillation using the second-generation cryoballoon.

Pulmonary Vein Isolation, Cryoballoon, Paroxysmal Atrial Fibrillation, Biophysical Parameters

Sanhoury, M. , Fassini, G. , Pala, S. , Moltrasio, M. , Tundo, F. , Riva, S. , Russo, A. , Casella, M. and Tondo, C. (2022) Study of the Impact of the Patient Rhythm during Cryoballoon Ablation on the Acute Biophysical Parameters. World Journal of Cardiovascular Diseases, 12, 65-76. doi: 10.4236/wjcd.2022.121007.