Author(s)

Jingjing Zhang¹, Dianbin Song², Yi Dong¹, Lu Bai¹, Dongqi Gao¹, Shenglin Zhang¹, Yan Guo¹, Fubo Li¹, Xiaolei Yu¹, Qingshan Li^1*

¹Department of Oncology, The Affiliated Hospital of Chengde Medical University, Chengde, China.
²Department of Urology, The Affiliated Hospital of Chengde Medical University, Chengde, China.

Objective: To investigate the changes of related immune cytokines (Dendritic Cells (DC) cells, CD4⁺, CD8⁺, Th17, IgG, IgM, IgA) in patients with non-small cell lung cancer (NSCLC) before and after chemotherapy. Methods: Eighty-five NSCLC patients who were treated in the Oncology Department of the Affiliated Hospital of Chengde Medical College from December 2018 to February 2021 were selected as the research objects, and the patients were analyzed at different time points (before chemotherapy, after the first chemotherapy, and after the second chemotherapy) Changes in the expression levels of DC cells, CD4⁺, CD8⁺, Th17, IgG, IgM, IgA in peripheral blood, and explore their correlation. Results: Before chemotherapy, after the first chemotherapy, and after the second chemotherapy, the peripheral blood CD4⁺ and CD8⁺ were significantly increased, and the Th17, IgG, IgM, and IgA levels gradually decreased. The difference was statistically significant. But there was no obvious change in DC cells. Conclusion: There is no significant change in DC cells in peripheral blood of NSCLC patients before and after chemotherapy. CD4⁺ and CD8⁺ are significantly increased, Th17, IgG, IgM, and IgA levels are all decreased, which is a manifestation of impaired immune function of patients after chemotherapy.

Non-Small Cell Lung Cancer, Chemotherapy, Immune-Related Factors

Zhang, J. , Song, D. , Dong, Y. , Bai, L. , Gao, D. , Zhang, S. , Guo, Y. , Li, F. , Yu, X. and Li, Q. (2022) Study on the Changes and Correlation of Related Immune Factors before and after Chemotherapy in Non-Small Cell Lung Cancer. International Journal of Clinical Medicine, 13, 50-56. doi: 10.4236/ijcm.2022.131004.