Author(s)

Dianbin Song¹, Zhiyong Wang^1*, Xiuming Li¹, Jingjing Zhang², Qiang Chi¹, Hui Xu¹, Hongyang Li¹, Ying Liu¹

¹Department of Urology, Affiliated Hospital of Chengde Medical College, Chengde, China.
²Department of Oncology, Affiliated Hospital of Chengde Medical College, Chengde, China.

Objective: To investigate the value of the number of circulating tumor cells (CTC) in peripheral blood in the prognosis and coagulation-related indicators of patients with renal cancer. Methods: 65 patients with renal cell carcinoma (RCC) confirmed pathologically were divided into CTC positive group and CTC negative group according to the CTC count (5 pcs/3.5 ml). Compare the age, gender, tumor location, TNM (clinical stage), pathological grade, tissue type, lymph node metastasis, distant metastasis, prognosis and prothrombin time (PT), fibrinogen (FIB), partial coagulation of the two groups of patients The correlation between the results of zymogen time (APTT) and D-dimer (DD) and the number of CTC. Results: There were significant differences in TNM, lymph node metastasis, and distant metastasis between the two groups (P < 0.05). The number of CTC in patients was correlated with FIB and D-D levels (P < 0.05). Conclusion: The number of CTC in patients with renal cell carcinoma is correlated with some clinical phenotypes (TNM, lymph node metastasis, distant metastasis) and some coagulation indexes (FIB, D-D), and can jointly predict the prognosis of renal cancer.

Peripheral Blood Circulating Tumor Cells, Renal Cancer, Clinical Phenotype, Coagulation Index

Song, D. , Wang, Z. , Li, X. , Zhang, J. , Chi, Q. , Xu, H. , Li, H. and Liu, Y. (2022) Application of Circulating Tumor Cells in Peripheral Blood in Judging the Prognosis of Patients with Renal Cancer and Related Indexes of Blood Coagulation. Open Journal of Urology, 12, 1-6. doi: 10.4236/oju.2022.121001.