Risk Factors for Preterm Delivery in Asymptomatic Singleton Pregnant Women with a Sonographic Short Cervix ()
ABSTRACT
Objectives: Although an asymptomatic short cervix is a risk factor for spontaneous
preterm birth (SPTB), the risk factors for SPTB among those with short cervix
remain unknown. We herein investigated risk factors for preterm delivery (PTD)
at <34 weeks of gestation in pregnant women with a short cervix. Methods: This was a retrospective study. Seventy-three asymptomatic pregnant women with
a sonographic short cervix (excluding visible bulging fetal membranes) were
selected, and the relationship between clinical or biochemical risk factors and
preterm delivery (PTD) at <34 weeks was examined. Results: Thirteen
cases (17.8%) had PTD at <34 weeks. A univariate analysis showed that a
history of SPTD, gestational weeks on admission, cervical length, cervical
mucus interleukin (CM-IL)-8 and amniotic fluid interleukin (AF-IL)-8 in PTD at
<34 weeks significantly differed from those in delivery at ≥34 weeks (p < 0.05, respectively). A multiple
logistic regression analysis identified CM-IL-8 ≥ 803.5 ng/mL [21.3 (3.0
- 260), p = 0.002] and cervical
length ≤15 mm [17.1 (1.9 - 517), p =
0.008] as independent risk factors for PTD at <34 weeks. Conclusions: Evaluation for cervical inflammation may be necessary for appropriate treatment
strategies in asymptomatic pregnant women with a short cervix. Cervical
inflammation warrants further study.
Share and Cite:
Yoneda, S. , Yoneda, N. and Saito, S. (2021) Risk Factors for Preterm Delivery in Asymptomatic Singleton Pregnant Women with a Sonographic Short Cervix.
Open Journal of Obstetrics and Gynecology,
11, 1711-1724. doi:
10.4236/ojog.2021.1112160.
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