Clinicopathological Data of Breast Cancer in Diabetic Patients ()
ABSTRACT
Background: Diabetes mellitus and breast cancer are both chronic diseases. Breast cancer in patients with diabetes is often
diagnosed at an advanced stage and has worse
prognosis. Aim of work: To investigate the clinicopathological factors,
hormonal receptor status and molecular subtypes of breast cancer in diabetic
breast cancer patients. Patients and methods: Records of patients
presenting to the radiotherapy committee of the breast cancer clinic of Ain
Shams University Hospital in the period between January 2017 and January 2018
were revised regarding age, presence of diabetes, presence of comorbidities,
and type of the surgery performed. Pathological data such as: Tumor size (T),
LN staging (LN), ER, PR, Her2/neu and Ki67 status were also recorded. Patients
were divided into 2 groups: Group (I): those with diabetes and Group (II): those without diabetes. Inclusion criteria were Breast cancer
cases with proven pathological diagnosis, available IHC studies, clear record
of comorbidity status, age > 18 years,
cases who underwent upfront surgery. Exclusion criteria were metastatic cases,
bilateral cases, cases with double primary, male breast cancer cases, and those
with missing data for ER, PR and Her2/neu. Results: Retrieving data from
the files of the patients that met the inclusion criteria in the allocated
period revealed that 117 patients had diabetes (Group I) and 199 didn’t have
the disease (Group II), There was a highly significant difference between both
groups regarding the age as most of the patients with diabetes were above fifty
years of age (84.6%) compared to only 44.7% of the patients without diabetes
also the mean age of patients with diabetes was significantly higher (59 years)
compared to 48 years of age for those without diabetes. Diabetes was associated
with hypertension in most of the cases (69%). Comorbidities other than
hypertension were recorded in 39 diabetic patients (33.3%) and 21 (10.6%)
nondiabetic patients and the difference was statistically highly significant.
In the diabetic group, the most encountered comorbidity was cardiac disease in 14.5% of
patients. In the diabetic group, most of
the patients underwent modified radical mastectomy (MRM) with a percentage of
about 54.7% compared to 48.2% of patients for both groups respectively.
Regarding pathological data apart from the finding that presence of diabetes
was associated with more multiple tumors (p value: 0.013), no other
statistically significant differences between both groups were found. Hormonal
receptor status and molecular subtypes were also not affected by presence of
diabetes in the studied breast cancer patients.
Share and Cite:
Adel, A. (2021) Clinicopathological Data of Breast Cancer in Diabetic Patients.
Journal of Cancer Therapy,
12, 663-673. doi:
10.4236/jct.2021.1212058.
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