Author(s)

Mosaad R. Mlahi¹, Mohsen M. Mostafa^2*

¹Faculty of Science, Department of Chemistry, Amran University, Amran, Yemen.
²Faculty of Science, Department of Chemistry, Mansoura University, Mansoura, Egypt.

New chelates derived from the novel ligand, (Z)-3-amino-N-(3-amino pyrazine-2-carbonyl)pyrazine-2-carbohydrazonic acid (APA, L), with Cu²⁺, Co²⁺, Pt⁴⁺ and Pd²⁺ salts were investigated. The results suggest that APA acts as mononegative tridentate in the case of Cu²⁺, binegative tetradentate in the case of Co²⁺ and as mononegative bidentate towards Pt⁴⁺ and Pd²⁺ chelates. The results of the corrected μ_eff. and spectral suggest the structures of the isolated chelates. The results of the corrected μ_eff. and spectral suggest the geometries of the isolated chelates. Molecular modeling is deduced and chemical reactivity, energy components for chelates and also MEP for APA is illustrated. In Vitro, the SOD and radical scavengers like activity of the synthesized compounds Hep G2 liver cancer cells and cytotoxic activity were checked. Metal chelates show potent anti-oxidative activity. The results of cytotoxic activity assay against hepatocellular carcinoma cell line Hep G2 confirmed that Pt⁴⁺ complex has the highest value, while APA, Cu²⁺, Co²⁺ and Pd²⁺ chelates have no significant cytotoxic activity.

Aminopyrazine, Density Function Theory Calculations, Antioxidant and Cytotoxic Activity, Biological Studies

Mlahi, M. and Mostafa, M. (2021) Structural, Theoretical and Biological Studies of (Z)-3-Amino-N-(3-Amino Pyrazine-2-Carbonyl) Pyrazine-2-Carbohydrazonic Acid (APA; L) and Its Cu²⁺, Co²⁺, Pt⁴⁺ and Pd²⁺ Chelates. Open Journal of Inorganic Chemistry, 11, 145-175. doi: 10.4236/ojic.2021.114010.