Correlation of Inflammatory Cells in Induced Sputum and Peripheral Blood of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease ()
Author(s)
Xin Wang1,2,
Di Wu3,
Yanmei Wu1,3,
Hongyan Liu1,
Ying Wang1,3,
Chunmei Yun1,3,
Dejun Sun1,2,3,
Xiaoyu Gao1*
Affiliation(s)
1Key Laboratory of National Health Commission for the Diagnosis & Treatment of COPD, Inner Mongolia Key Laboratory of Respira-tory Diseases, Inner Mongolia People’s Hospital, Hohhot, China.
2Department of Geriatric Medicine, Inner Mongolia People’s Hospital, Hohhot, China.
3Department of Respiratory and Critical Care Medicine, Inner Mongolia People’s Hospital, Hohhot, China.
ABSTRACT
Chronic obstructive pulmonary disease (COPD) is a major chronic respiratory disease worldwide. Inflammatory
cells reflect the inflammatory situation both in
peripheral blood and induced sputum. Their correlation has not been reported. The correlation between
neutrophils (Neu), eosinophils (Eos), and lymphocyte (Lym) in induced sputum
and that in peripheral blood of COPD patients
was evaluated to explore
the consistency of inflammatory cells in peripheral blood
and induced sputum. Peripheral blood and induced sputum were collected from 437 patients
with acute exacerbation of COPD (AECOPD) who
were hospitalized in the Department of respiratory and critical care medicine,
Inner Mongolia People’s Hospital. The correlation
analysis was performed by Spearman correlation analysis. The
ratios of Neu,
Eos, and Lym in induced sputum were (79.15 ± 22.60)%, (5.23 ± 12.74)%, and
(1.69 ± 2.66)%. The ratios of Neu, Eos, and Lym in peripheral blood were (63.29 ± 11.44)%, (2.99 ± 3.60)%, and (25.16 ± 10.19)%. The results
showed that the ratios of Neu and Eos in induced sputum were significantly
correlated with the proportion of corresponding cells in peripheral blood (P < 0.05). There was no correlation between the ratio of
Lym and Leu in induced sputum and corresponding cells in peripheral
blood (P > 0.05). In patients with AECOPD, the
tendency of Neu and Eos in induced sputum was consistent with the
corresponding cells in peripheral blood. Neu and Eos in induced
sputum and peripheral blood reflected the degree of inflammation to
guide the individualized medication of patients.
Share and Cite:
Wang, X. , Wu, D. , Wu, Y. , Liu, H. , Wang, Y. , Yun, C. , Sun, D. and Gao, X. (2021) Correlation of Inflammatory Cells in Induced Sputum and Peripheral Blood of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Open Journal of Respiratory Diseases,
11, 105-115. doi:
10.4236/ojrd.2021.113010.
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