Author(s)

Lidiane Aparecida Vila Pires¹, Ricardo José Tofano^1,2,3, Sandra Maria Barbalho^1,2,4,5*, Claudia Rucco Penteado Detregiachi^1,2,5, Marcelo Dib Bechara¹, Viviane Alessandra Capelluppi Tofano¹, Jesselina Francisco dos Santos Haber^1,5, Eduardo Federighi Baisi Chagas^2,5, Ana Maria Gonçalvez Milla², Karina Quesada¹

¹School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.
²Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), São Paulo, Brazil.
³Cardiology Unit of the UNIMAR Beneficent Hospital (HBU), Marilia, São Paulo, Brazil.
⁴Department of Biochemistry and Nutrition, Faculty of Food Technology of Marília, Marília, São Paulo, Brazil.
⁵CENID (Interdisciplinary Center on Diabetes)—UNIMAR—Marília, São Paulo, Brazil.

The Lipid Accumulation Product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovascular risk and mortality. The aim of this study was to verify the association of LAP with anthropometric, biochemical, visceral adiposity index and IR in adults and the elderly. This single cross-section center clinical study, with experimental, analytical, primary, and observational design, included 210 participants. Anthropometric (Body Mass Index (BMI), Waist Circumference (WC), and Neck Circumference (NC)), LAP, Visceral Adipose Index (VAI), and biochemical parameters (fasting glycemia, insulinemia (to calculate the Homa-IR index), total cholesterol, LDL-c, HDL-c, and triglycerides) were evaluated. The results showed that by separating the sample into three groups (adequate BMI and WC, adequate BMI and elevated WC, and elevated BMI and WC), the group with high BMI and WC showed a high value of LAP and VAI compared to the other groups, with a significant difference. Still, the data show a positive and significant correlation when relating the LAP with VAI, HOMA-IR, BMI, WC, NC, total cholesterol, triglycerides, and Diastolic Blood Pressure. It also showed an inversely proportional relationship when associating LAP with HDL-c (p < 0.0001). Thus, we show that LAP is closely related to visceral adiposity, IR, altered lipid parameters, and blood pressure, especially diastolic in the patients included in our study. For these reasons, we suggest that LAP is a reliable indicator of promising visceral adiposity for early detection of cardiovascular risk in the adult and senior population.

Lipid Accumulation Product, Obesity. Visceral Obesity, Metabolic Syndrome, Cardiovascular Risk

Pires, L. , Tofano, R. , Barbalho, S. , Detregiachi, C. , Bechara, M. , Tofano, V. , Haber, J. , Chagas, E. , Milla, A. and Quesada, K. (2021) Lipid Accumulation Product: Reliable Marker for Cardiovascular Risk Detection?. Open Journal of Epidemiology, 11, 267-277. doi: 10.4236/ojepi.2021.113023.