Author(s)

Huirong Ying¹, Jinna Zhang², Chengjun Jiang^2*

¹Zhejiang Hisoar Pharmaceutical Co., Ltd., Taizhou, China.
²School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China.

The focus of this investigation was to prepare the cocrystal of carbamazepine (CBZ) using nicotinamide as a coformer and to compare its different preparation methods. The cocrystal was prepared by grinding, solvent-Assisted grinding and ultrasound-assisted cocrystallization methods. They were characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and morphology by electron microscopy. In conclusion, ultrasound can be applied as a process intensification parameter along with cooling or slurry cocrystallization to produce pure cocrystals under conditions that might result in crystal mixtures in conventional processes.

Carbamazepine, Nicotinamide, Cocrystal, Ultrasound

Ying, H.R., Zhang, J.N. and Jiang, C.J. (2021) Preparation of Carbamazepine-Nicotinamide Cocrystal. Open Access Library Journal, 8, 1-8. doi: 10.4236/oalib.1107605.