Author(s)

Souleymane Mariko^1*, Massama Konaté², Samba Sidibé³, Karamoko Kantako¹, Charles Dara¹, Djibril Kassogué⁴, Nouhoum Diallo³, Coumba A. Thiam⁵, Aniessa Kodio⁶, Mariam Sako³, Abdoul Karim Sacko³, Mamadou Diakité³, Souleymane Coulibaly³, Ilo Bella Diall³, Ichaka Menta⁷

¹General Medicine Service, Tombouctou Hospital, Tombouctou, Mali.
²Cardiology Department, Mali Hospital, Bamako, Mali.
³Cardiology Department Point G Hospital University Center, Bamako, Mali.
⁴Department of Pediatrics, Tombouctou Hospital, Tombouctou, Mali.
⁵Cardiology Department Kati Hospital University Center, Kati, Mali.
⁶Cardiology Department, Ségou Hospital, Ségou, Mali.
⁷Cardiology Department Gabriel Touré Hospital University Center, Bamako, Mali.

Introduction: Peripartum cardiomyopathy (PPCM) is a heart failure whose etiology is still unknown. The aim of work was to study peripartum cardiomyopathy in its epidemiological, clinical, paraclinical and therapeutic aspects at the Tombouctou hospital. Methods: This is a descriptive cross-sectional study carried out in the Medicine Department of the Timbuktu hospital from January 1 to December 31, 2019. It concerned patients who presented heart failure between the 8th month of pregnancy and the first 5 months postpartum. Results: During the study,23 patients were collected. Average age of the patients was 23.50 ± 3.50 years with extremes of 16 and 34 years. Incidence of Peripartum cardiomyopathy (PPCM) was 1/345 pregnancies. Average parity was 3.20 with extremes of 1 and 8. Symptoms appeared at postpartum with 87% of cases. A significant delay in diagnosis was observed. Global heart failure was the mode of decompensation with 70%. Electrocardiographic signs were mainly sinus tachycardia (87%) and left ventricular hypertrophy (83%). Cardiac ultrasound showed in all cases dilated cardiomyopathy and it was associated with thrombus in left ventricle cavity for three cases. Left ventricular ejection fraction was severely impaired in 70% of cases. Pulmonary hypertension was significant in 52%. Most commonly drugs we used in our series at acute stage were duretics: furosemide 100% and spironolactone 70% (100% and 70%) and ACE inhibitors (90%). Beta-blockers (bisoprolol and carvedilol) were used in 15 patients. Bromocriptine (prolactin inhibitor) was used for 2 patients. Conclusion: Peripartum cardiomyopathy is a serious cardiac complication of pregnancy of unknown cause, common in the African population.

Heart Failure, Cardiomyopathy, Peripartum, Treatment

Mariko, S. , Konaté, M. , Sidibé, S. , Kantako, K. , Dara, C. , Kassogué, D. , Diallo, N. , Thiam, C. , Kodio, A. , Sako, M. , Sacko, A. , Diakité, M. , Coulibaly, S. , Diall, I. and Menta, I. (2021) Peripartum Cardiomyopathy: Epidemiological, Clinical, Para-Clinical and Therapeutic Aspects at the Tombouctou Hospital. World Journal of Cardiovascular Diseases, 11, 167-180. doi: 10.4236/wjcd.2021.113018.