Author(s)

Ali Bouattour¹, Mehdi Fakhfakh¹, Souhir Abid El-Gharbi², Majdi Abid², Ludovic Paquin^3,4, Rémy Le Guevel⁵, Thierry Charlier⁵, Houcine Ammar¹, Jean-Pierre Bazureau^3,4*

¹Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax, Sfax, Tunisie.
²Chemistry Department, College of Science and Arts, Jouf University, Al Qurayyat, Al Jawf, KSA.
³Institut des Sciences Chimiques de Rennes, ISCR UMR CNRS 6226, Campus Beaulieu, Université de Rennes 1, Bat. 10A, Rennes Cedex, France.
⁴S2Wave Platform, ScanMAT UMS 2001 CNRS, Campus Beaulieu, Université de Rennes 1, Bat. 10A, Rennes Cedex, France.
⁵ImPACcell Platform, SFR Biosit Bat. 8, Campus Villejean, Rennes Cedex, France.

The first report of new 3-(tetrazol-5-yl)-2-iminocoumarin derivatives is described. The title compounds were prepared in two steps and were obtained in good yields (55-93%). They have been fully characterized by ¹H, ¹³C NMR, FTIR, UV-Visible and HRMS. They were tested for their antiproliferative activities against six representative human tumor cell lines (Huh 7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and HaCat keratinocytes. Among them, compound 5e was active on HCT 116 (IC₅₀ 15 μM).

2-Iminocoumarin, Tetrazole, Fluorescence, Tumor Cell Lines, HCT 116

Bouattour, A. , Fakhfakh, M. , El-Gharbi, S. , Abid, M. , Paquin, L. , Le Guevel, R. , Charlier, T. , Ammar, H. and Bazureau, J. (2021) 3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines. International Journal of Organic Chemistry, 11, 24-34. doi: 10.4236/ijoc.2021.111003.