Author(s)

Wei Chen^1,2,3*, Junwen Ye^1,2,3*, Xiaoping Tan^4*, Yan Zhang^2,3,5, Jinglin Liang^1,2,3#, Meijin Huang^1,2,3#

¹Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
²Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
³Guangdong Research Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
⁴Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁵Department of Medicine Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: The purpose of this study was to observe the factors related to T4 patients who underwent surgery for colorectal cancer (CRC) with peritoneal carcinomatosis. Methods: 154 T4 colorectal cancer patients who underwent surgery in the first Affiliated Hospital of Sun Yat-sen University were included in the study between August, 1994 and December, 2005. Some clinical variables were selected and statistically correlated with prognosis. Results: The overall survival time was 91.7 months at the end of December of 2010 or death. The complete cytoreduction had significant survival benefit than the palliative surgery group. The age, location, histological grade, complete cytoreduction and liver metastasis were associated with overall survival time (OS) according to the univariate analysis (P < 0.05). In addition, Cox multivariate analysis showed that the complete cytoreduction (CCR) and liver metastasis were independent factor influencing survival. Conclusion: Compared with palliative surgery, the incomplete cytoreduction fails to improve patient prognosis. Patients performed completed cytoreduction have a relative good prognosis.

Colorectal Cancer, Peritoneal Carcinomatosis, Surgery, Prognosis

Chen, W. , Ye, J. , Tan, X. , Zhang, Y. , Liang, J. and Huang, M. (2021) Analysis of 154 T4 Colorectal Cancer Patients with Peritoneal Carcinomatosis Treated by Surgery. International Journal of Clinical Medicine, 12, 61-70. doi: 10.4236/ijcm.2021.122008.