Author(s)

Abed Al Aziz Al Quntar^1,2*, Hasan Dweik², Ahmad Jabareen¹, Tatyana A. Gloriozova³, Valery M. Dembitsky⁴

¹Department of Material Engineering, Faculty of Engineering, Al-Quds University, Jerusalem, Palestine.
²Faculty of Chemistry and Chemical Technology, Al-Quds University, Jerusalem, Palestine.
³Institute of Biomedical Chemistry, Moscow, Russia.
⁴Centre for Applied Research and Innovation, and Entrepreneurship, Lethbridge College, Lethbridge, Canada.

A novel class of aminopyrrolidinyl phosphonates was synthesized in 74% - 80% isolated yield by the addition of three-fold excess of primary amines to diethyl 4-chloro-1-butynylphosphonates. The reaction was carried out at room temperature and in the absence of solvent or catalyst to give solely compounds which showed predicted biological activity based on PASS program. Some of the synthesized derivatives of antibiotics exhibit properties for the treatment of stroke, the treatment of acute neurological disorders, and can also be acetyl esterase inhibitors.

Alkynylphosphonates, Cyclization, Pyrrolidine, β-Aminophosphonates, Amine Addition, Antibiotics

Al Quntar, A. , Dweik, H. , Jabareen, A. , Gloriozova, T. and Dembitsky, V. (2020) An Aminopyrrolidinyl Phosphonates—A New Class of Antibiotics: Facile Synthesis and Predicted Biological Activity. International Journal of Organic Chemistry, 10, 170-181. doi: 10.4236/ijoc.2020.104013.