Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-Membered 1,3-Disubstituted Cyclic Amidinium Salts - Open Journal of Medicinal Chemistry

OJMC > Vol.10 No.4, December 2020

Volume 10, Issue 4 (December 2020)

ISSN Print: 2164-3121 ISSN Online: 2164-313X

Google-based Impact Factor: 0.71 Citations

Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-Membered 1,3-Disubstituted Cyclic Amidinium Salts ()

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DOI: 10.4236/ojmc.2020.104008 300 Downloads 1,116 Views

Author(s)

María M. Blanco¹, María A. Reamírez¹, María C. Caterina¹, Isabel A. Perillo¹, Guido A. Oppezzo¹, María S. Shmidt¹, Gabriel O. Gutkind², José Di Conza², Alejandra Salerno^1*

Affiliation(s)

¹Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
²Departamento de Microbiología, Inmunología y Biotecnología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.

ABSTRACT

Series of 1,3-dibenzyl-1H-4,5,6,7-tetrahydro-1,3-diazepinium and 1,4,5,6,7,8-hexahydro-1,3-diazocinium salts derivatives were efficiently synthesized in excellent yields by dehydrogenation of the corresponding N,N'-dibenzyl aminals employing N-bromosuccinimide (NBS) as dehydrogenating agent under ultrasound irradiation. The present methodology has proven to be simple, efficient and environmentally benign. All novel compounds were identified and characterized by ¹H and ¹³C NMR spectra. The synthesized compounds were screened for their antimicrobial activities.

KEYWORDS

Medium Ring Amidinium Salts, Ultrasonic Assisted Synthesis, Antimicrobial, Green Chemistry

Share and Cite:

Blanco, M. , Reamírez, M. , Caterina, M. , Perillo, I. , Oppezzo, G. , Shmidt, M. , Gutkind, G. , Di Conza, J. and Salerno, A. (2020) Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-Membered 1,3-Disubstituted Cyclic Amidinium Salts. Open Journal of Medicinal Chemistry, 10, 139-152. doi: 10.4236/ojmc.2020.104008.

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