Author(s)

Glaucia Labinas, Fernando Amaral, Valeria Maria de Souza Antunes, Maira Jardim, Leonardo Mendes Bella, Carlos Rocha Oliveira^*

Universidade Anhembi Morumbi, São Paulo, Brazil.

Background: Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of Trichoxidil^TM, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. Methods: The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of Trichoxidil^TM. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5); Trichosol^TM vehicle group, without active (n = 5); Hydroalcoholic vehicle group, without active (n = 4); Trichosol^TM vehicle group, with 2.5% minoxidil (n = 5); Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5); Trichosol^TM group with 2.5% Trichoxidil^TM (n = 5) and Hydroalcoholic vehicle group with 2.5% Trichoxidil^TM (n = 4) to dermoscopic and histologic. Results: Fibroblasts exhibited higher proliferation when treated with higher concentrations of Trichoxidil^TM. Trichoxidil^TM significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that Trichoxidil^TM associated with Trichosol^TM vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. Conclusion: Trichoxidil^TM promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.

TrichoxidilTM, Hair Growth, Anagen, Telogen, KGF, IGF-1

Labinas, G. , Amaral, F. , de Souza Antunes, V. , Jardim, M. , Bella, L. and Oliveira, C. (2020) Hair Growth Promoting Effect of TrichoxidilTM: A New Natural Compound for Hair Loss. Journal of Cosmetics, Dermatological Sciences and Applications, 10, 176-190. doi: 10.4236/jcdsa.2020.104019.