Author(s)

Min Guo¹, Juncheng Guo², Yunsuo Gao¹, Xiaodan Wang^3*

¹Hainan General Hospital, Haikou, China.
²Central South University Xiangya School of Medical Affiliated Haikou Hospital, Haikou, China.
³School of Public Health, Hainan Medical University, Haikou, China.

Objective: To explore the distribution characteristics of BDNF gene frequency in Li and Han nationalities in Hainan province. Methods: In June 2018-2019 and march to the people’s hospital of Hainan province health volunteers, 152 cases (Li 80, Han, 72), the application of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to detect the polymorphism of BDNF gene (rs6265), and compared with other countries and regions of ethnic comparison between BDNF gene frequency distribution. Results: No statistical difference was found in rs6265 genotype distribution of BDNF gene in Li and Han ethnic groups (P = 0.3358, P = 0.0892, P = 0.1549). Comparison of BDNF allele frequency between Li and other ethnic groups showed statistically significant differences with other ethnic groups in China and Europe (P = 0.0384, P = 0.0000), but not statistically significant differences with Japan (P = 0.1164). Conclusion: BDNF gene (rs6265) has polymorphism in both Li and Han ethnic groups in Hainan Province. Compared with ethnic groups in other countries and regions, the polymorphism distribution is ethnically different.

BDNF Gene, The PCR-RFLP, Alleles, Genotype

Guo, M. , Guo, J. , Gao, Y. and Wang, X. (2020) BDNF Gene Frequency Distribution in Li and Han Ethnic Groups in Hainan Province and Its Comparison with Other Countries and Regions. Journal of Behavioral and Brain Science, 10, 531-536. doi: 10.4236/jbbs.2020.1012032.