ABSTRACT
Objective: To investigate the protein expression and clinicopathological
characteristics of ABCG2, Oct4, Nanog in laryngeal cancer tissues, and to seek new molecular markers for
the diagnosis of laryngeal cancer. Methods: The laryngeal cancer tissues and paracancerous tissues of 87 patients
with laryngeal carcinoma diagnosed in the department of otorhinolaryngology and
head and neck surgery in our hospital from April 2016 to April 2018 were
selected as the subjects. QRT-PCR, Real-time PcR, Western blot and
immunohistochemical staining were used to detect the expression of ABCG2, Oct4
and Nanog in (Tumor Tissue) and (Adjacent Tissue) in tumor tissue and
paracancerous tissue. Results: The results of RT-PCR showed that the positive rates of ABCG2, Oct4 and
Nanog in laryngeal carcinoma tissues were 49.30%, 45.07% and 52.11%,
respectively, while those in paracancerous tissues were 22.54%, 21.13% and 15.49%, respectively (P < 0.01). The expression of
ABCG2, Oct4 and Nanog in laryngeal carcinoma was correlated with tumor
differentiation, depth of invasion, age and sex (P < 0.05), but not with
tumor size and TNM stage. Conclusion: The expressions of ABCG2, Oct4 and Nanog in cancer tissues are related to
tumor differentiation status, and they can be used as new molecular markers for
the diagnosis of laryngeal cancer.
Share and Cite:
Tan, Y. , Wu, X. , Li, S. , Wang, X. , Fu, G. , Xie, L. , Wu, Y. and Han, Q. (2020) The Expression and Clinical Significance of ABCG2, Oct4 and Nanog in Laryngeal Carcinoma.
Journal of Cancer Therapy,
11, 660-672. doi:
10.4236/jct.2020.1111056.