Author(s)

Mariama Kaba Combasséré-Chérif^1,2, Hadidjatou Belem^1*, Benjamin Koama^1,3, Assetou Sawadogo¹, Sandrine Nadège Da¹, Windmi Kagambéga¹, Anne-Flora Drabo¹, Roland Nâg-Tiéro Meda¹, George Anicet Ouédraogo¹

¹Laboratory for Research and education in Animal Health and Biotechnologies, Nazi Boni University, Bobo-Dioulasso, Burkina Faso.
²Health Action Research Group, Ouagadougou, Burkina Faso.
³Laboratory of Pharmacology, Research Institute in Health Sciences, Bobo-Dioulasso, Burkina Faso.

Two medicinal plants, Gardenia erubescens and Fadogia agrestis were selected to evaluate their biological activities. Their total phenolic and flavonoid contents were assessed using folin-ciocalteu and aluminum chloride regents’ methods. The antioxidant activity was estimated using DPPH (1,1-diphényl-2-picrylhydrazyl), ABTS (2,2’-azinobis-[3-ethylenzothiazoline-6-sulfonic acid]) and FRAP (ferric reducing antioxidant power). The antiplasmodial activity of the extracts was determined in vivo on 42 NMRI mice. The results indicate that all the extracts from both two plants contain some polyphenols. The ethanolic extract of the leaves of Gardenia erubescens showed the best antioxidant activity by the method of DPPH. The aqueous extracts of the leaves of Gardenia erubescens and the whole plant of Fadogia agrestis have a reducing power similar to control (quercetin). All the extracts have a low capacity to scavenge the ABTS radical cation compared to the controls (trolox and quercetin). Concerning the antiplasmodial activity, all the extracts presented moderate antiplamodial activities. This result could justify the traditional uses of Gardenia erubescens and Fadogia agrestis to treat of malaria in Burkina Faso.

Antiplasmodial Activity, Antioxidant Activity, Gardenia erubescens, Fadogia agrestis

Combasséré-Chérif, M. , Belem, H. , Koama, B. , Sawadogo, A. , Da, S. , Kagambéga, W. , Drabo, A. , Meda, R. and Ouédraogo, G. (2020) Antioxidant and Antiplasmodial Activities of Extracts from Gardenia erubescens Stapf et Hutch. and Fadogia agrestis Schweinf. ex Hiern. (Rubiaceae). Open Journal of Applied Sciences, 10, 675-687. doi: 10.4236/ojapps.2020.1011047.