The Role of HER2/Neu and BRCA1 Genes in the Diagnosis of Breast Cancer among Sudanese Women - Journal of Cancer Therapy

JCT > Vol.11 No.8, August 2020

Journal of Cancer Therapy

Volume 11, Issue 8 (August 2020)

ISSN Print: 2151-1934 ISSN Online: 2151-1942

Google-based Impact Factor: 0.30 Citations h5-index & Ranking

The Role of HER2/Neu and BRCA1 Genes in the Diagnosis of Breast Cancer among Sudanese Women ()

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Download as PDF (Size: 297KB) PP. 491-496

DOI: 10.4236/jct.2020.118042 399 Downloads 1,354 Views Citations

Author(s)

Mohamed Ahmed Osman^1,2, Faris Merghani Eltom^1,3*, Mohamed Elzubier Abdallah^4,5, Saad Ali S. Aljohani⁶

Affiliation(s)

¹Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan.
²Department of Anatomy and Histology, Faculty of Medicine, Batterjee Medical College, Jeddah, KSA.
³Department of Histology, College of Medicine, Alrayan Colleges, Almadinah Almunawwarah, KSA.
⁴Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, KSA.
⁵Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.
⁶Department of Basic Medical Science, Faculty of Medicine, Alrayan Colleges, Almadinah Almunawarah, KSA.

ABSTRACT

Background: Knowledge of HER2/Neu and BRCA1 Genes might be helpful for development of strategies for decreasing the burden of risk of breast cancer. Therefore, the aim of this study to detect the role of HER2/Neu and BRCA1 Genes expression in diagnosis of breast cancer in Sudanese women. Methodology: A total of 100 tissue samples obtained from patients with breast cancer in addition to 50 tissue samples obtained from patients with benign breast lesions, were detected the expression of HER2/Neu and BRCA1 Genes by Polymerase Chain Reaction (PCR). Results: The prevalence of HER2/Neu and BRCA1 Genes, among cases was 6%, and 10% respectively. Conclusion: HER2/Neu and BRCA1 Genes have a considerable contribution to etiology of breast cancer in Sudan that requires further consideration.

KEYWORDS

HER2/Neu and BRCA1 Genes, Breast Cancer, Sudan

Share and Cite:

Osman, M. , Eltom, F. , Abdallah, M. and Aljohani, S. (2020) The Role of HER2/Neu and BRCA1 Genes in the Diagnosis of Breast Cancer among Sudanese Women. Journal of Cancer Therapy, 11, 491-496. doi: 10.4236/jct.2020.118042.

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