Open Journal of Inorganic Non-metallic Materials

Volume 10, Issue 2 (April 2020)

ISSN Print: 2164-6791   ISSN Online: 2164-6805

Google-based Impact Factor: 0.67  Citations  

Coordination Behavior and Biological Activity of Some Transition Metal Complexes with 2-Acetyl and 2-Formyl-3-Amino-1,4-Naphthoquinone Ligands

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DOI: 10.4236/ojinm.2020.102002    1,172 Downloads   3,109 Views  Citations

ABSTRACT

The aim of this work is to synthesize, characterize and evaluate the biological activity of 2-acetyl and 2-formyl-3-amino-1,4-naphthoquinone (L1 - L2) and their metal-Co(II), Ni(II) and Cu(II) chelates. The newly chelates were characterized by elemental analysis, IR, mass and 1HNMR spectra, thermogravimetric analysis (TGA) and biological activity. The antibacterial and antifungal activities of the ligands and its metal complexes were screened against bacterial species (Staphylococcus aureus, Bacillus subtilis and Escherichia coli) and fungi (Candida albicans). Ampicillin and amphotericin were used as references for antibacterial and antifungal studies. The activity data show that the metal complexes have a promising biological activity comparable with parent free ligand against bacterial and fungal species.

Share and Cite:

Hassan, F. , Fayez, M. and Abdalla, N. (2020) Coordination Behavior and Biological Activity of Some Transition Metal Complexes with 2-Acetyl and 2-Formyl-3-Amino-1,4-Naphthoquinone Ligands. Open Journal of Inorganic Non-metallic Materials, 10, 15-29. doi: 10.4236/ojinm.2020.102002.
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