Author(s)

Chioma Don-Lawson¹, Daniel Okechukwu Nweneka¹, Reminus Okah¹, Kingsley J. Orie²

¹Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Port Harcourt, Nigeria.
²Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria.

This study reports the synthesis of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane, characterisation and bioactivities on selected microorganism. The first step involves the coupling of furfural with urea to obtain 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea, which was subsequently refluxed with more urea in ethanol for 1 hour to afford the product. Both intermediate and product were characterized by GC-MS, IR, ¹H-NMR, ¹³C-NMR. The synthesized compound1,1-bis(2-carbamoylguanidino)furan-2-ylmethane was bioactive on Escherichia coli, Salmomellatyphi and Bacillus subtilis to different extent and is inactive on Staphylococcus aureus. The presences of bioactive moieties and pharmacological activities have proved the potency of furfural derivatives in the development of novel drug in future.

Furfural, 1, 1-bis(2-Carbamoylguanidino)furan-2-ylmethane, Bioactivity

Don-Lawson, C., Nweneka, D.O., Okah, R. and Orie, K.J. (2020) Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane. American Journal of Analytical Chemistry, 11, 261-268. doi: 10.4236/ajac.2020.116020.