In-Host Analysis of Malaria Dynamics in Humans ()
ABSTRACT
Human
malaria infection poses a major global health threat worldwide. Yet, no
sophisticated mathematical model exists to study the complex dynamics and interactions between the parasites and
host immune response at the blood and liver stages. In this paper, an in-host
mathematical model of Plasmodium falciparum malaria dynamics and interactions
in an infected host cells are studied at the liver stage by incorporating the
red blood cells and the immune system. Numerical simulations are applied to
investigate the interactions between the host immune response, the parasite
dynamics, and the disease dynamics at both the blood and liver stages. Results
show that immunity has a
significant impact in clearing infected red blood cells. Furthermore, the
infected erythrocytes and hence the severity of malaria tend to increase with
increasing density of merozoites in the blood. The result revealed that
intervention during malaria infection should focus on minimizing merozoite
invasion rate on healthy erythrocytes and the density of merozoites in
circulation.
Share and Cite:
Annan, K. (2020) In-Host Analysis of Malaria Dynamics in Humans.
Open Journal of Applied Sciences,
10, 191-209. doi:
10.4236/ojapps.2020.105015.