Vietnam has opened its doors to innovation for the past 32 years and has affirmed that the Communist Party and government’s reform methodologies have brought with them countless achievements. The economy has been opened up and at the same time it has welcomed cultural waves from other countries. The Vietnamese culture, while preserving its own identity, has been embracing the cultural quintessence of other races. This cultural interference that has formed and brought more clarity in the cultural and spiritual life of the society, is a driving force for economic development. This article aims to find the answer to the question: How do the Vietnamese and the world cultural interactions promote and motivate Vietnam’s economic development at present and in future. Hence, the article is organized into three main parts: Firstly, the introduction introduces the significance and purpose as well as limitation of the article. Secondly, Culture and cultural interference reviews some definitions, theories, principles and discuss more about them. Thirdly, Practice present analyzing the Vietnam phenomenon in aspects like culture and economy. Finally, Suggestion will discuss solutions for cultural interference in Vietnam.