Author(s)

Hani Yousif Zaki^*, Ahmed Abbi Abdille, Badreldin Elsonni Abdalla

Department of Biochemistry and Nutrition, Faculty of Medicine, University of Gezira, Wad Medani, Sudan.

Objective: In this study, we assessed the level of fasting C-peptide as a predictor of β-cell function and insulin resistance in patients with Type 2 diabetes mellitus (T2DM), Gezira State-Sudan. Methods: In this cross-sectional study, 100 T2DM patients attending the Diabetic patients care Centre were recruited, thirty five patients were males and sixty five were females, the mean age of the patients was 50.29 ± 0.456 years, and body mass index (BMI) was 26.54 ± 0.437. We estimated β-cell function using fasting C-peptide levels; homeostatic model assessment for β-cell function (HOMA-B) and insulin resistance (HOMA-IR) were calculated from C-peptide and fasting blood glucose (FBG). Results: C-peptide was significantly and positively correlated with HOMA-B and HOMA-IR. FBG also showed significant negative correlation with HOMA-B, but was positively and significantly correlated with HOMA-IR. HbA1c was negatively and significantly correlated with HOMA-B. Patients with low C-peptide levels had increased FBG and HbA1c level, while patients with high C-peptide levels were having high HOMA-IR and HOMA-B. Conclusions: Fasting C-peptide is a useful marker of pancreatic β-cell function, and its circulating levels could be used to evaluate insulin secretion and insulin resistance. Moreover, HOMA-IR is an effective index to achieve glycemic control by appropriate pharmacologic treatment of T2DM.

β-Cell Function, C-Peptide, Insulin Resistance, Type 2 Diabetes Mellitus

Zaki, H. , Abdille, A. and Abdalla, B. (2019) Level of Fasting C-Peptide as a Predictor of β-Cell Function in Sudanese Patients with Type 2 Diabetes Mellitus. Journal of Biosciences and Medicines, 7, 115-123. doi: 10.4236/jbm.2019.71010.