Author(s)

Yang Zhang, Chen Tu, Shuang Wang, Shengxiang Xiao^*

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, China.

The epidermis represents an essential barrier versus a broad range of exogenous stimuli. To form a functional epidermis, keratinocytes express filaggrin which plays a vital role in atopic dermatitis. However the relationship between filaggrin and other skin diseases remains unknown. In our study we chose 5 different common skin diseases and analyzed the expression of filaggrin in the skin using immunohistochemistry. Imiquimod (IMQ)-induced mouse model was used for detecting the filaggrin level and barrier function. The results indicated that the expression of filaggrin is reduced in psoriasis compared to the other skin diseases. Furthermore in vivo study showed that the skin barrier is defected with a decreased expression of filaggrin in IMQ-induced psoriasis mouse model, which is accompanied with an increased level of IL-17/IL-23. In conclusion, the defective skin barrier is involved in the development of psoriasis in human and mice with a reduced expression of filaggrin which may be regulated by the increased level of IL-17/IL-23 in the skin.

Skin Barrier, Psoriasis, Filaggrin, Atopic Dermatits

Zhang, Y. , Tu, C. , Wang, S. and Xiao, S. (2018) Expression of Skin Barrier Protein Filaggrin in Skin Diseases without Atopic Dermatitis. Journal of Biosciences and Medicines, 6, 101-112. doi: 10.4236/jbm.2018.61009.