The volumetric flow rate of smoke generated from the fire in large space often reaches to hundreds of thousands CMH because of extended floor height and as it’s more difficult to isolate the smoke to the limited area, comparing to normal-scale building, design and operation of effective smoke control system for large space is more than important. In this study, with the analysis model for such a large space as exhibition hall or conference room in conventional center, design of mechanical smoke exhaust system was conducted based on currently-available design standard which was then followed by numerical analysis of the design using 3D numerical analysis method. For conference room at 2.0 MW heat release rate, 99,173 CMH flow rate is required, if smoke layer is maintained at 60% of the floor height and for exhibition hall at 8.8 MW with 80% of floor height, flow rate required is 219,802 CMH, which are incorporated into the design. In view of 3D numerical analysis, accuracy of the design according to algebraic expression is sufficient.