Author(s)

M. Elmahdy^1*, Sameh S. Sadek¹, A. Elmarsafawy¹, D. Elkafash², Azza Elhenawy¹

¹Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
²Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: One of the serious problems affecting pregnant females is Hyperemesis gravidarum. Different theories were suggested. But the main etiology is still unknown. Objectives: To determine the incidence of Helicobacter pylori infection in cases of Hyperemesis gravidarum. Patients and methods: Case control study of 80 cases (40 cases of Hyperemesis gravidarum (HEG) and 40 cases of normal pregnant females). Determination of Helicobacter pylori antibodies was done in serum and stool for the two studied groups. Results: 75% of cases of HEG were positive of Helicobacter pylori in stool samples and 37.50% of normal pregnant females. These results were statistically significant (P = 0.001). The prevalence of HpIgG AB and HpSAB was 77.5% in the patients group with HEG, and 55.0% in control studied group (P = 0.05). There was a significant difference between HEG cases and normal pregnancy as regards serum sodium (0.042). Conclusions: Infection by Helicobacter pylori may be one of the risk factors for HEG. Helicobacter pylori AB in both serum and stool is higher in HEG cases than in normal pregnant females.

HEG, H. pylori, Pregnancy

Elmahdy, M. , Sadek, S. , Elmarsafawy, A. , Elkafash, D. and Elhenawy, A. (2017) Incidence of Helicobacter Pylori Infection in Cases of Hyperemesis Gravidarum. Open Journal of Obstetrics and Gynecology, 7, 411-419. doi: 10.4236/ojog.2017.74043.