Risk Factors for Cervical Cancer in a Sample Comprising Three Generations of Brazilian Women - Journal of Cancer Therapy

JCT > Vol.8 No.1, January 2017

Risk Factors for Cervical Cancer in a Sample Comprising Three Generations of Brazilian Women ()

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DOI: 10.4236/jct.2017.81002 1,553 Downloads 3,496 Views Citations

Author(s)

Ilce Ferreira da Silva^1*, Rosalina Jorge Koifman², Virgilio Augusto Gomes Parreira³, Simone Soares³, Sergio Koifman²

Affiliation(s)

¹Instituto Fernandes Figueira, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
²Escola Nacional de Saúde Pública, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
³Hospital do Cancer-II, Instituto Nacional do Cancer, Rio de Janeiro, Brazil.

ABSTRACT

Background: Cervical cancer is the main cause of cancer deaths in some developing countries. Age-related cervical cancer incidence has been fundamental for understanding the different stages of carcinogenesis concepts. No Brazilian study explored the environmental risk factors involved on cervical cancer, according to age groups taking 70’s sexual revolution in Brazil as reference. Aim: To determine the prevalence of epidemiological and clinical aspects related to cervical cancer development in a sample of three age groups of Brazilian women based on 70’s sexual revolution. Methods: A cross-section study was proceeded in a hospital-based cohort of women with altered Pap-test refereed to the National Cancer Institute for Colposcopy and treatment from October 2004 to May 2006. Two register nurses interviewed all patients ascertaining risk factors and clinical characteristics. Biopsy, partial ablation were used for CIN-1, and conization was the treatment for CIN-2/3. Results: From 318 women included in the study, 42.8% were 18 - 30 years old (born after 1975), 43.4% were 31 - 49 years old (born 1955-1975), and 13.8% were 50 - 68 years old (born 1936-1954). Pregnancies (OR = 1.16; CI95%: 1.01 - 1.34) and menarche under 12 years old (OR = 1.95; CI95%: 1.17 - 3.25) were independently associated to CIN2- 3/cancer in 18 - 30 age group; menopause age (OR = 1.21; CI95%: 1.04 - 1.41) and current smoking habit (OR = 1.37; CI95%: 1.10 - 1.70) were associated to CIN2- 3/cancer in 31 - 49 age group; no statistical significance was observed for 50 - 68 age group. Conclusion: Brazilian women present distinct risk for cervical cancer according to the generation they belong, when taking the Brazilian sexual revolution on 70’s as a reference.

KEYWORDS

Cervical Cancer, Cross-Section Study, Epidemiology, Sexual Revolution, Brazil

Share and Cite:

da Silva, I. , Koifman, R. , Parreira, V. , Soares, S. and Koifman, S. (2017) Risk Factors for Cervical Cancer in a Sample Comprising Three Generations of Brazilian Women. Journal of Cancer Therapy, 8, 12-25. doi: 10.4236/jct.2017.81002.

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