Author(s)

Harioly Nirina Marie Osé Michael¹, Hoahy Rasoanandrasana¹, Raheritiana Todisoa Mahenina¹, Rasolonjatovo Anjaramalala Sitraka², Rakoto Alson Aimée Olivat¹, Rasamindrakotroka Andry³

¹Haematology Laboratory of University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar.
²Medecine Service of University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.
³Medical Biology Laboratory Faravohitra, Antananarivo, Madagascar.

Introduction: Chronic Myeloid Leukemia is a myeloproliferative disorder affecting hematopoietic stem cells. The specific cytogenetic abnormality is translocation (9; 22) which leads to the BCR-ABL fusion gene. Methods: We did a bone marrow aspiration in our laboratory of haematology of university hospital Joseph Ravoahangy Andrianavalona Antananarivo. We studied myelogram and compared its result to the cytogenetic result. Results: Men were the most affected by this pathology and diagnostic average age was 51.2 years. Splenomegaly leukocytosis and myelemia were often present. Myelogram showed granulocytic hyperplasia and the t (9; 22) were present in all the patients. Conclusion: Diagnosis is based on data from the NFS, the myelogram, the search for the Philadelphia chromosome and BCR-ABL fusion gene. These specialized techniques are still inaccessible for Malagasy patients.

Chronic Myeloid Leukemia, Madagascar, t (9; 22), BCR-ABL

Michael, H. , Rasoanandrasana, H. , Mahenina, R. , Sitraka, R. , Olivat, R. and Andry, R. (2016) Confrontation between Myelogram and Cytogenetics in 35 CML Malagasy Patients. Journal of Cancer Therapy, 7, 919-923. doi: 10.4236/jct.2016.712089.