Author(s)

Saqer Al Mualla¹, Raed Farahat¹, Pierre Basmaji², Gabriel Molina de Olyveira^3*, Ligia Maria Manzine Costa⁴, José Domingos da Costa Oliveira², Gino Bruno Francozo²

¹Al Qassimi Hospital/Kuwait Hospital, Sharjah, United Arab Emirates.
²Innovatec’s-Biotechnology Research and Development, São Carlos, Brazil.
³Department of Physical Chemistry, Universidade Estadual Paulista (UNESP), Araraquara, Brazil.
⁴Materials Engineering Department, São Carlos School of Engineering, University of São Paulo, São Carlos, Brazil.

Natural extracellular matrices (ECMs) perform the tasks necessary for tissue formation, maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials. In addition, biomedical materials have claimed attention because of the increased interest in tissue engineering materials for wound care and regenerative medicine. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this work, we present the extracellular matrix (ECM) using the bacterial cellulose (Nanoskin^®) which regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. Bacterial cellulose fermentation process is modified before the bacteria are inoculated for mimicking ECM to cells support and built new local material for wound healing. Chemical groups influences and thermal behavior in bacterial cellulose were analyzed using transmission infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), respectively. Besides, In vivo analysis was evaluated with clinical study at Sharjah Kuwait Hospital.

Bacterial Cellulose (Nanoskin), Natural Nanocomposites, Regenerative Medicine, Stem Cells

Mualla, S. , Farahat, R. , Basmaji, P. , Olyveira, G. , Costa, L. , Oliveira, J. and Francozo, G. (2016) Study of Nanoskin ECM-Bacterial Cellulose Wound Healing/United Arab Emirates. Journal of Biomaterials and Nanobiotechnology, 7, 109-117. doi: 10.4236/jbnb.2016.72012.