Author(s)

Zhixin Wang¹, Ruiyao Zhang¹, Kai Qu¹, Yanyan Zhou¹, Wei Chen¹, Xinsen Xu¹, Fandi Meng¹, Jichao Wei¹, Minghui Tai¹, Jingyao Zhang¹, Lingqiang Zhang¹, Yuelang Zhang², Chang Liu¹

¹Department of Hepatobiliary Surgery, The First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, China.
²Department of Radiology, The First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an, China.

Objective: To discuss the etiology, diagnosis and treatment of central pontine myelinolysis (CPM) by analyzing 4 cases of our center and 26 cases reported by others in our country. Methods: We analyzed the clinical feature, diagnosis and treatment of 4 CPM cases and then compared them with 26 CPM cases reported between 2000 and 2010. Results: The average age of our 4 cases (3 men and 1 woman) was 47.5 years old. All cases were diagnosed by MRI scan. The patients all had been diagnosed as liver cirrhosis and most of the CPM related symptoms were observed within 2 weeks after surgery, including neural and psychic symptoms and physical impairment. Rapid correction of hyponatremia during perioperative period and high blood concentration of FK506 may be the main causes. All cases received etiological and symptomatic combination treatment and were continued with neural function training after hospital discharge. A long-term follow-up (29.5 ± 15.0 months) showed an improvement of neural function to different degrees. Conclusion: CPM after liver transplantation is a severe complication, of which the etiology and pathogenesis were not clear. MRI scan is the main method for confirmative diagnosis. Etiological prevention and timely treatment may improve the prognosis.

Liver Transplantation, Central Pontine Myelinolysis, Clinical Analysis

Wang, Z. , Zhang, R. , Qu, K. , Zhou, Y. , Chen, W. , Xu, X. , Meng, F. , Wei, J. , Tai, M. , Zhang, J. , Zhang, L. , Zhang, Y. and Liu, C. (2014) Clinical Analysis of Central Pontine Myelinolysis after Liver Transplantation. Open Access Library Journal, 1, 1-8. doi: 10.4236/oalib.1100759.