Author(s)

Jan Fransaer, Malika Ammam

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Previous work illustrated that glucose oxidase (GOx) could be deposited on conducting substrates using asymmetrical alternating current electrophoretic deposition (AC-EPD) to form thick enzyme layers suitable for the manufacturing of highly active biosensors. Here, we modeled the amperometric response of GOx layers to glucose as a function of the thickness of the enzyme layer. The model is based on reaction-diffusion equations with irreversible first-order catalytic reactions. The numerical results displayed qualitative and reasonable quantitative agreement with the experimental data obtained for oxidation currents due to glucose, which increase with the enzyme thickness.

Alternating Current Electrophoretic Deposition, Glucose Oxidase, Modeling

J. Fransaer and M. Ammam, "Mathematical Modeling of the Amperometric Response to Glucose of Glucose Oxidase Films Deposited by AC-Electrophoresis," Journal of Sensor Technology, Vol. 1 No. 2, 2011, pp. 17-21. doi: 10.4236/jst.2011.12003.