LPS Regulates Apolipoprotein E and Aβ Interactionswith Effects on Acute Phase Proteins and Amyloidosis - Advances in Aging Research

AAR > Vol.4 No.2, March 2015

LPS Regulates Apolipoprotein E and Aβ Interactionswith Effects on Acute Phase Proteins and Amyloidosis ()

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DOI: 10.4236/aar.2015.42009 5,382 Downloads 6,638 Views Citations

Author(s)

Ian James Martins^1,2,3

Affiliation(s)

¹Centre of Excellence in Alzheimer’s Disease Research and Care School of Medical Sciences, Edith Cowan University, Joondalup, Australia.
²School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Nedlands, Australia.
³McCusker Alzheimer’s Research Foundation, Holywood Medical Centre, Nedlands, Australia.

ABSTRACT

Interactions between apolipoprotein E (apo E) and amyloid beta (Aβ) are associated with the peripheral clearance of Aβ and are important to the development of neurodegenerative diseases. Interests in acute phase proteins (APP) as biomarkers for the early progression of Alzheimer’s disease indicate that the peripheral Aβ metabolism is perturbed and the role of nutritional diets are important to reduce APPs to maintain peripheral Aβ clearance with relevance to hepatic cholesterol homeostasis and brain amyloidosis. The role of nutriproteomic diets that reverse the effects of high fat diets are associated with the reduction in APPs, cholesterol homeostasis and improved clearance of Aβ. Nutritional diets that reduce the increase in plasma endotoxins (gut microbiotica) such as lipopolysaccarides (LPS) reduce the effects of LPS on cell membranes and increase the cellular uptake of Aβ by interactions with apo E. LPS alter hepatic lipid metabolism with an increase hepatic cytokines and APPs in plasma. Interactions between apo E and Aβ are altered by LPS with increased binding of LPS to apo E with effects on electrostatic alterations in Aβ oligomers. The role of LPS in neurodegenerative diseases includes the effects of LPS on alpha-synuclein metabolism with relevance to Parkinson’s disease and Alzheimer’s disease

KEYWORDS

Lipopolysaccharides, Apolipoprotein E, Amyloid Beta, Acute Phase Protein, Diet

Share and Cite:

Martins, I. (2015) LPS Regulates Apolipoprotein E and Aβ Interactionswith Effects on Acute Phase Proteins and Amyloidosis. Advances in Aging Research, 4, 69-77. doi: 10.4236/aar.2015.42009.

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