Recent Advances in Treatment for Uremic Pruritus - Open Journal of Nephrology

OJNeph > Vol.5 No.1, March 2015

Recent Advances in Treatment for Uremic Pruritus ()

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DOI: 10.4236/ojneph.2015.51001 5,315 Downloads 7,560 Views Citations

Author(s)

Hiromichi Suzuki^1*, Hiroshi Omata², Hiroo Kumagai³

Affiliation(s)

¹Department of Nephrology, Saitama Medical University, Moroyama, Japan.
²Center for Oriental and Integrated Medicine, Saitama Medical University, Moroyama, Japan.
³Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Japan.

ABSTRACT

This review highlights recent advances in pathophysiology and treatment for uremic pruritus, especially focusing on various interventions. Pruritus in patients on hemodialysis (HD) and peritoneal dialysis (PD) still remains an unresolved issue. Recently, the efficacy and safety of nalfurafine hydrochloride have been reported in Japan, and at present, more than thirty thousand patients receive this new drug. In comparison with the efficacy of this new drug, acupuncture, a form of traditional Japanese therapy, has been validated for relief of symptoms of pruritus. In this review, various interventions for relief of symptoms of pruritus as well as recent studies on its pathophysiology will be introduced. This review will be helpful for treatment of pruritus in patients on dialyzed therapy in clinical practice.

KEYWORDS

Itch, Dialysis, Ultraviolet, Topical Ointment, Acupuncture, Opioid Antagonists, Nalfurafine

Share and Cite:

Suzuki, H. , Omata, H. and Kumagai, H. (2015) Recent Advances in Treatment for Uremic Pruritus. Open Journal of Nephrology, 5, 1-13. doi: 10.4236/ojneph.2015.51001.

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