Author(s)

Laura Boldrini, Mirella Giordano, Adele Servadio, Greta Alì, Alice Cocco, Marco Lucchi, Pietro Bertoglio, Franca Melfi, Alfredo Mussi, Gabriella Fontanini

Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Unit of Pathological Anatomy III, Azienda Ospedaliera Universitaria Pisana (A.O.U.P.), Pisa, Italy.
Unit of Thoracic Surgery, Azienda Ospedaliera Universitaria Pisana (A.O.U.P.), Pisa, Italy.

Background: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of miRNA let-7, miR-21, and miR-205 are inconclusive. The aim of the present analysis was therefore to evaluate the expression and the prognostic role of the above mentioned miRNAs in early-stage (T1N0) NSCLC patients. Methods: Quantification of let-7g, miR-21, and miR-205 expression was carried out into 105 early-stage NSCLC by quantitative Real Time-PCR (qRT-PCR). Results: a significant association between the low miR-205 expression and ADC histotype (p < 0.0001) compared to SCC was found; moreover, survival analysis showed thattumors with a high miR-205 expression had a significantly shorter mean PFS and OS compared to the patients with a low expression of this miRNA (p = 0.02 and p = 0.03, respectively). No other statistically significant correlations were observed between the analysed miRNAs and the main clinico-pathological characteristics of the NSCLC patients. Conclusion: The results indicated that miR-205 could represent a useful marker in the prognostic management of the early-stage (T1N0) NSCLC patients.

Non-Small Cell Lung Cancer, miR-21, let-7g, miR-205, Prognosis

Boldrini, L. , Giordano, M. , Servadio, A. , Alì, G. , Cocco, A. , Lucchi, M. , Bertoglio, P. , Melfi, F. , Mussi, A. and Fontanini, G. (2014) Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer. Advances in Lung Cancer, 3, 45-51. doi: 10.4236/alc.2014.32007.