The results of the study of the formation of graphene layers in the flame in premixed flame propane or butane-oxygen mixture on a nickel substrate at atmospheric pressure and low pressure are given. The influence of the ratio C/O and supply quantity of argon on the formation of graphene layers were researched. It is shown that in the flame of propane and butane on a nickel substrate is observed under these conditions the formation of predominantly 3 - 10 layers of graphene.