Author(s)

Renato Iovine, Valeria Loscrí, Sara Pizzi, Richard Tarparelli, Anna Maria Vegni

Department of Engineering, University of Roma Tre, Rome, Italy.
Dipartimento di Ingegneria dell’Informazione, delle Infrastrutture e dell’Energia Sostenibile (DIIES), Mediterranea University of Reggio Calabria, Reggio Calabria, Italy.
Dipartimento di Ingegneria Informatica, Modellistica (DIMES), Elettronica e Sistemistica, University of Calabria, Cosenza, Italy.

In this paper, we present a multi-source nanonetwork model for biomedical diagnosis applications, based on the Localized Surface Plasmon Resonance by different shape gold nanoparticles (i.e., cylinder, cube, and rod). We present the process of multi-source emission, diffusion, and reception of nanoparticles, based on the ligand/receptor binding. Then, a multi-detection process of DNA alterations is accomplished when nanoparticles are captured at the receiver. The colloidal particles are selectively functionalized with specific splice junctions of gene sequences to reveal simultaneously different alteration that could be associated to an early disease condition. Particularly, full-wave simulations have been carried out for the multi-detection of alternative splice junctions of breast cancer susceptibility gene 1. The proposed application is verified through numerical results and expressed in terms of Extinction-Cross Section, in the case of synchronous and asynchronous nanoparticles detection. We show that the proposed approach is able to detect DNA alterations, based on a selective nanoparticle reception process.

Nanoparticles; Nanonetworks; LSPR; DNA Alterations; BRCA1

Iovine, R. , Loscrí, V. , Pizzi, S. , Tarparelli, R. and Vegni, A. (2013) Model of Multi-Source Nanonetworks for the Detection of BRCA1 DNA Alterations Based on LSPR Phenomenon. Advances in Nanoparticles, 2, 301-312. doi: 10.4236/anp.2013.24041.