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Prof. Daniela Quaglino

University of Modena and Reggio Emilia, Italy


Email: daniela.quaglino@unimore.it



1992  Ph.D., University of Bologna, Italy

1984  B.Sc., University of Modena, Italy


Publications (Selected)

  1. Quaglino D., Boraldi F., Barbieri D., Croce R., Tiozzo R., Pasquali Ronchetti I. Abnormal phenotype of in vitro dermal fibroblasts from patients with pseudoxanthoma elasticum (PXE). Biochim.Biophys. Acta, 1501: 51-62, 2000
  2. Le Saux O., Urban Z., Tschuch C., Csizar K., Bacchelli B., Quaglino D., Pasquali Ronchetti I., Pope FM., Richards A., Terry S., Bercovitch L., De Paepe A., Boyd CD. Mutations in a gene encoding an ABC transporter (ABCC6) cause Pseudoxanthoma elasticum. Nature Genetics, 25:223-227, 2000
  3. Capri M., Quaglino D., Verzella G., Monti D., Bonafe M., Cossarizza A., Troiano L.,.Zecca L., Pasquali Ronchetti I., Franceschi C. A cytofluorimetric study of T lymphocyte subsets in rat lymphoid tissues (thymus, lymph nodes) and peripheral blood: A continuous remodelling during the first year of life. Exp. Gerontol., 35: 613-625, 2000
  4. Quaglino D., Capri M., Pasquali Ronchetti I. Modulation of cell death in the rat thymus. Light and electron microscopic investigations. Ann.N.Y.Acad. Sci.USA, 926:79-82, 2000
  5. Quaglino D., Pasquali Ronchetti I. Cell death in the rat thymus: a minireview. Apoptosis 6: 389-401, 2001
  6. Baritussio A., Marzini S., Agostani M., Alberti A., Cimenti C., Bruttomesso D., Manzato E., Quaglino D., Pettenazzo A. Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes. Am.J. Physiol. 281: L1189-99,2001.
  7. Zhu Y, Lin L, Kim S, Quaglino D., Lockshin RA, Zakeri Z. Cyclin dependent kinase 5 and its interacting proteins in cell death induced in vivo by cyclophosphamide in developing mouse embryos. Cell Death Differ. 9:421-30, 2002
  8. Boraldi F., Bini L., Liberatori S., Armini A., Pallini V., Tiozzo R., Pasquali-Ronchetti-I., Quaglino D. Normal human dermal fibroblasts: Proteomic analysis of cell layer and culture medium. Electrophoresis, 24: 1292-1310, 2003
  9. Boraldi F., Bini L., Liberatori S., Armini A., Pallini V., Tiozzo R., Pasquali-Ronchetti-I., Quaglino D. Proteome analysis of dermal fibroblasts cultured in vitro from human healthy subjects of different ages. Proteomics, 3: 917-929, 2003
  10. Boraldi F., Quaglino D., Croce M.A., Garcia Fernandez MI., Tiozzo R., Gheduzzi D., Bacchelli B., Pasquali Ronchetti I. Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients Matrix Biol. 22:491-500, 2003
  11. Quaglino D., Ha HR., Duner E., Bruttomesso D., Bigler L., Follath F., Reali G., Pettenazzo A., Baritussio A. Effects of metabolites and analogues of amiodarone on alveolar macrophages: structure-activity relationship. Am J Physiol Lung Cell Mol Physiol. 287:L438-47, 2004
  12. Quaglino D., Boraldi F., Bini L., Volpi. N. The protein profile of fibroblasts: the role of proteomics. Current Proteomics, 1: 167-178, 2004
  13. Gheduzzi D., Guidetti R., Anzivino C., Tarugi P., Di Leo E., Quaglino D., Pasquali Ronchetti I. ABCC6 mutations in Italian families affected by pseudoxanthoma elasticum (PXE). Hum Mutat. 24: 438-439, 2004 and #775, pp 1-10 online, 2004
  14. Tamburro AM, Pepe A, Bochicchio B, Quaglino D, Pasquali-Ronchetti I.Supramolecular amyloid-like assembly of the polypeptide sequence coded by exon 30 of human tropoelastin. J Biol Chem. 280:2682-90, 2005
  15. Gheduzzi D, Guerra D, Bochicchio B, Pepe A, Tamburro AM, Quaglino D, Mithieux S, Weiss AS, Pasquali Ronchetti I.Heparan sulphate interacts with tropoelastin, with some tropoelastin peptides and is present in human dermis elastic fibers. Matrix Biol. 24:15-25, 2005
  16. Quaglino D., Sartor L., Garbisa, S., Boraldi F., Croce A., Passi A., De Luca G., Tiozzo R., Pasquali-Ronchetti I. Dermal fibroblasts from Pseudoxanthoma elasticum patients have raised MMP-2 degradative potential. Biochim. Biophys. Acta, 1741: 42-47, 2005
  17. Pepe A, Guerra D, Bochicchio B, Quaglino D, Gheduzzi D, Pasquali Ronchetti I, Tamburro AM. Dissection of human tropoelastin: Supramolecular organization of polypeptide sequences coded by particular exons.Matrix Biol. 24:96-109, 2005.
  18. Pasquali Ronchetti I., Gracia-Fernandez MI., Boraldi F., Quaglino D., Ghedizzi D., Paolinelli DeVincenzi C., Tiozzo R., Bergamini S., Ceccarelli D., Muscatello U. Oxidative stress in fibroblsdtas from patients with pseudoxanthoma elasticum: possibile role in the pathogenesis of clinical manifestations. J. Pathol., 208: 54-61, 2006
  19. Gheduzzi D, Boraldi F, Annovi G, DeVincenzi CP, Schurgers LJ, Vermeer C, Quaglino D, Pasquali-Ronchetti I. Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients. Lab Invest. 87:998-1008, 2007
  20. Boraldi F, Annovi G, Carraro F, Naldini A, Tiozzo R, Sommer P, Quaglino D. Hypoxia influences the cellular cross-talk of human dermal fibroblasts. A proteomic approach. Biochim Biophys Acta. 1774:1402-13, 2007
  21. Boraldi F. Annovi G., Paolinelli-Devincenzi C., Tiozzo R., Quaglino D. The effect of serum withdrawal on the protein profile of quiescent human dermal fibroblasts in primary cell culture. Proteomics 8:66-82, 2008
  22. Pezet M, Jacob MP, Escoubet B, Gheduzzi D, Tillet E, Perret P, Huber P, Quaglino D, Vranckx R, Li DY, Starcher B, Boyle WA, Mecham RP, Faury G. Elastin Haploinsufficiency Induces Alternative Aging Processes in the Aorta. Rejuvenation Res. 11: 97-112, 2008
  23. Pepe A., Flamis R., Guerra D., Quaglino D., Bochicchio B., Pasquali-Ronchetti I., Tamburo AM. Exon 26-coded polipeptide: an isolated hydrophobic domain of human tropoelastin able to self-assemble in vitro. Matrix Biology, 27:441-50,2008
  24. Garcia-Fernandez MI, Gheduzzi D, Boraldi F, Paolinelli CD, Sanchez P, Valdivielso P, Morilla MJ, Quaglino D, Guerra D, Casolari S, Bercovitch L, Pasquali-Ronchetti I. Parameters of oxidative stress are present in the circulation of PXE patients.Biochim Biophys Acta. 1782:474-81, 2008
  25. Boraldi F., Annovi G., Guerra D., Paolinelli DeVincenzi C., Garcia-Fernandez MI., Panico F., De Santis G., Tiozzo R., Ronchetti I.Quaglino D. Fibroblast protein profile analysis highlights the role of oxidative stress and vitamin-K recycling in the pathogenesis of Pseudoxanthoma elasticum. Proteomics-Clin.Appl., 3: 1-15 2009