Prof. Zhirui Wang

Department of Materials Science and Engineering

University of Toronto, Canada

Professor

Email: zhirui.wang@utoronto.ca

Qualifications

1986 PDF, University of Pennsylvania

1985 Ph.D., Polytechnic University of New York

1982 M.ASc., Polytechnic University of New York

1968 B.Eng., Jiaotong University

Publications (Selected)

1. Ma, J., Wang, Z., Mintzlaff, D., Zhang, H., Ramakrishna, R., Davila, E., ... & Wang, Z. (2025). Bivalent CD47 immunotoxin for targeted therapy of T-cell acute lymphoblastic leukemia. Blood, 145(5), 508-519.
2. Navarro-Alvarez, N., Wang, Z., Duran-Struuck, R., Neville, P., Liu, A., Chen, S., ... & Huang, C. A. (2024). P. 547: Tolerogenic properties of CD3 immunotoxin induction therapy and progress toward clinical trials in transplantation. Transplantation, 108(9S).
3. Wang, Z., Ramakrishna, R., Wang, Y., Qiu, Y., Ma, J., Mintzlaff, D., ... & Wang, Z. (2024). Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs. European Journal of Pharmacology, 968, 176408.
4. Wang, Z., Ma, J., Zhang, H., Ramakrishna, R., Mintzlaff, D., Mathes, D. W., ... & Wang, Z. (2023). CCR4‐IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T‐cell lymphoma in a mouse CTCL model. FEBS Open Bio, 13(7), 1309-1319.
5. Qiu, Y., Qi, Z., Wang, Z., Cao, Y., Lu, L., Zhang, H., ... & Wang, Z. (2022). EGF-IL2 bispecific and bivalent EGF fusion toxin efficacy against syngeneic head and neck cancer mouse models. Oncology Reports, 49(2), 37.
6. Qi, Z., Qiu, Y., Wang, Z., Zhang, H., Lu, L., Liu, Y., ... & Wang, Z. (2021). A novel diphtheria toxin‐based bivalent human EGF fusion toxin for treatment of head and neck squamous cell carcinoma. Molecular Oncology, 15(4), 1054-1068.
7. Wang, H., Wang, Z., Zhang, H., Qi, Z., Johnson, A. C., Mathes, D., ... & Wang, Z. (2020). Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma. Molecular Oncology, 14(5), 991-1000.
8. Corti, F., Wang, Y., Rhodes, J. M., Atri, D., Archer-Hartmann, S., Zhang, J., ... & Simons, M. (2019). N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization. Nature communications, 10(1), 1562.
9. Corti, F., Wang, Y., Rhodes, J. M., Atri, D., Archer-Hartmann, S., Zhang, J., ... & Simons, M. (2019). N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization. Nature communications, 10(1), 1562.
10. Wang, Z., Louras, N. J., Lellouch, A. G., Pratts, S. G., Zhang, H., Wang, H., ... & Wang, Z. (2018). Dosing optimization of CCR 4 immunotoxin for improved depletion of CCR 4+ Treg in nonhuman primates. Molecular Oncology, 12(8), 1374-1382.
11. Navarro‐Alvarez, N., Goncalves, B., Andrews, A. R., Wang, Z., Wang, Z., Harrington, E., ... & Huang, C. A. (2018). The effects of galectin‐3 depletion apheresis on induced skin inflammation in a porcine model. Journal of clinical apheresis, 33(4), 486-493.
12. Zheng, Q., Wang, Z., Zhang, H., Huang, Q., Madsen, J. C., Sachs, D. H., ... & Wang, Z. (2017). Diphtheria toxin‐based anti‐human CD 19 immunotoxin for targeting human CD 19+ tumors. Molecular oncology, 11(5), 584-594.
13. Eliaz, I., Patil, A., Navarro‐Alvarez, N., Wang, Z., Eliaz, A., Weil, E., ... & Huang, C. A. (2017). Methods for the detection and serum depletion of porcine galectin‐3. Journal of Clinical Apheresis, 32(5), 335-341.
14. Wang, Z., Navarro-Alvarez, N., Shah, J. A., Zhang, H., Huang, Q., Zheng, Q., ... & Wang, Z. (2016). Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Veterinary immunology and immunopathology, 182, 150-158.
15. Gou, G., Chen, J., Wang, Z., Chen, H., Ma, C., & Li, P. (2016). Stress corrosion cracking behavior of 4.19% Zn-1.34% Mg (A7N01S-T5) aluminum alloy welded joints. Corrosion, 72(9), 1133-1145.
16. Kwan, C. C., Li, Z., & Wang, Z. (2015). Progression of late stage abnormal grain growth of electroformed nanocrystalline Ni without the addition of grain refiner. Metallurgical and Materials Transactions A, 46, 4636-4645.
17. Hsu, T. Y. J., & Wang, Z. (2014). Cyclic stress–strain response and microstructure evolution of polycrystalline Cu under pure compressive cyclic loading condition. Materials Science and Engineering: A, 615, 302-312.

Profile Details

https://mse.utoronto.ca/faculty-staff/professors-emeriti/wang/

https://www.researchgate.net/profile/Zhirui-Wang-2