Biography

Dr. Manuel Narváez Peláez

Department of Human Physiology and Sport Medicine, Faculty of Medicine

University of Málaga, Spain


Email: mnarvaez@uma.es


Qualifications

2012 Ph.D., University of Malaga, Spain

2005 M.D., Medicine and Surgery, University of Malaga, Spain


Publications (Selected)

  1. Beltran-Casanueva, R., Hernández-García, A., Serrano-Castro, P. J., Sánchez-Pérez, J. A., Barbancho-Fernández, M. A., García-Casares, N., Fuxe, K., Borroto-Escuela, D. O., & Narváez, M. (2024). Long-term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co-administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38(7), e23595. https://doi.org/10.1096/fj.202400087R
  2. Sánchez-Varo, R., López-Salas, A., Beltran-Casanueva, R., Díaz-Sánchez, E., Alvarez-Contino, J. E., Barbancho-Fernández, M. A., Serrano-Castro, P., Fuxe, K., Borroto-Escuela, D. O., García-Casares, N., & Narváez, M. (2024). Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions. Behavioral and brain functions : BBF, 20(1), 6. https://doi.org/10.1186/s12993-024-00230-5
  3. Alvarez-Contino, J. E., Díaz-Sánchez, E., Mirchandani-Duque, M., Sánchez-Pérez, J. A., Barbancho, M. A., López-Salas, A., García-Casares, N., Fuxe, K., Borroto-Escuela, D. O., & Narváez, M. (2023). GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions. Journal of cellular physiology, 238(2), 459–474. https://doi.org/10.1002/jcp.30944
  4. Romero-Fernandez, W., Taura, J. J., Crans, R. A. J., Lopez-Cano, M., Fores-Pons, R., Narváez, M., Carlsson, J., Ciruela, F., Fuxe, K., & Borroto-Escuela, D. O. (2022). The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson's Disease. Molecular neurobiology, 59(10), 5955–5969. https://doi.org/10.1007/s12035-022-02946-9
  5. Mirchandani-Duque, M., Barbancho, M. A., López-Salas, A., Alvarez-Contino, J. E., García-Casares, N., Fuxe, K., Borroto-Escuela, D. O., & Narváez, M. (2022). Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory. Biomedicines, 10(6), 1297. https://doi.org/10.3390/biomedicines10061297
  6. Borroto-Escuela, D. O., Ferraro, L., Beggiato, S., Narváez, M., Fores-Pons, R., Alvarez-Contino, J. E., Wydra, K., Frankowska, M., Bader, M., Filip, M., & Fuxe, K. (2021). Correction to: The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons. Pharmacological reports : PR, 73(5), 1484. https://doi.org/10.1007/s43440-021-00326-z
  7. Borroto-Escuela, D. O., Ambrogini, P., Narvaez, M., Di Liberto, V., Beggiato, S., Ferraro, L., Fores-Pons, R., Alvarez-Contino, J. E., Lopez-Salas, A., Mudò, G., Díaz-Cabiale, Z., & Fuxe, K. (2021). Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia-Relevance for Mental Diseases. Cells, 10(8), 1902. https://doi.org/10.3390/cells10081902
  8. Borroto-Escuela, D. O., Pita-Rodriguez, M., Fores-Pons, R., Barbancho, M. A., Fuxe, K., & Narváez, M. (2021). Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus. Journal of cellular physiology, 236(5), 3565–3578. https://doi.org/10.1002/jcp.30092
  9. Borroto-Escuela, D. O., Narváez, M., Romero-Fernández, W., Pinton, L., Wydra, K., Filip, M., Beggiato, S., Tanganelli, S., Ferraro, L., & Fuxe, K. (2019). Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes. Molecular neurobiology, 56(10), 7045–7055. https://doi.org/10.1007/s12035-019-1580-8
  10. Borroto-Escuela, D. O., Perez De La Mora, M., Manger, P., Narváez, M., Beggiato, S., Crespo-Ramírez, M., Navarro, G., Wydra, K., Díaz-Cabiale, Z., Rivera, A., Ferraro, L., Tanganelli, S., Filip, M., Franco, R., & Fuxe, K. (2018). Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors. Frontiers in synaptic neuroscience, 10, 20. https://doi.org/10.3389/fnsyn.2018.00020
  11. Borroto-Escuela, D. O., DuPont, C. M., Li, X., Savelli, D., Lattanzi, D., Srivastava, I., Narváez, M., Di Palma, M., Barbieri, E., Andrade-Talavera, Y., Cuppini, R., Odagaki, Y., Palkovits, M., Ambrogini, P., Lindskog, M., & Fuxe, K. (2017). Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression. Frontiers in cellular neuroscience, 11, 309. https://doi.org/10.3389/fncel.2017.00309
  12. Millón, C., Flores-Burgess, A., Narváez, M., Borroto-Escuela, D. O., Santín, L., Gago, B., Narváez, J. A., Fuxe, K., & Díaz-Cabiale, Z. (2016). Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system. Brain structure & function, 221(9), 4491–4504. https://doi.org/10.1007/s00429-015-1180-y
  13. Narváez, M., Borroto-Escuela, D. O., Millón, C., Gago, B., Flores-Burgess, A., Santín, L., Fuxe, K., Narváez, J. A., & Díaz-Cabiale, Z. (2016). Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects. Brain structure & function, 221(8), 4129–4139. https://doi.org/10.1007/s00429-015-1153-1
  14. Borroto-Escuela, D. O., Narvaez, M., Di Palma, M., Calvo, F., Rodriguez, D., Millon, C., Carlsson, J., Agnati, L. F., Garriga, P., Díaz-Cabiale, Z., & Fuxe, K. (2014). Preferential activation by galanin 1-15 fragment of the GalR1 protomer of a GalR1-GalR2 heteroreceptor complex. Biochemical and biophysical research communications, 452(3), 347–353. https://doi.org/10.1016/j.bbrc.2014.08.061
  15. Borroto-Escuela DO, Romero-Fernandez W, Garriga P, Ciruela F, Narvaez M, Tarakanov AO, Palkovits M, Agnati LF, Fuxe K. G protein-coupled receptor heterodimerization in the brain. Methods Enzymol. 2013;521:281-94.
  16. Fuxe K, Borroto-Escuela DO, Romero-Fernandez W, Tarakanov AO, Calvo F, Garriga P, Tena M, Narvaez M, Millón C, Parrado C, Ciruela F, Agnati LF, Narvaez JA, Díaz-Cabiale Z. On the existence and function of galanin receptor heteromers in the central nervous system. Front Endocrinol (Lausanne). 2012;3:127
  17. Borroto-Escuela DO, Romero-Fernandez W, Pérez-Alea M, Narvaez M, Tarakanov AO, Mudó G, Agnati LF, Ciruela F, Belluardo N, Fuxe K. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity. J Neurosci. 2012 May 2;32(18):6295-303.
  18. Borroto-Escuela DO, Romero-Fernandez W, Mudó G, Pérez-Alea M, Ciruela F, Tarakanov AO, Narvaez M, Di Liberto V, Agnati LF, Belluardo N, Fuxe K. Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity. Biol Psychiatry. 2012 Jan 1;71(1):84-91
  19. Romero-Fernandez W, Borroto-Escuela DO, Tarakanov AO, Mudó G, Narvaez M, Pérez-Alea M, Agnati LF, Ciruela F, Belluardo N, Fuxe K. Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family. Biochem Biophys Res Commun. 2011 Jun 17;409(4):764-8
  20. Díaz-Cabiale Z, Parrado C, Narváez M, Puigcerver A, Millón C, Santín L, Fuxe K, Narváez JA. Galanin receptor/Neuropeptide Y receptor interactions in the dorsal raphe nucleus of the rat. Neuropharmacology. 2011 Jul-Aug;61(1-2):80-6
  21. Díaz-Cabiale Z, Parrado C, Narváez M, Millón C, Puigcerver A, Fuxe K, Narváez JA. Neurochemical modulation of central cardiovascular control: the integrative role of galanin. EXS. 2010;102:113-31
  22. Borroto-Escuela DO, Correia PA, Romero-Fernandez W, Narvaez M, Fuxe K, Ciruela F, Garriga P . Muscarinic receptor family interacting proteins: role in receptor function. J Neurosci Methods. 2011 Feb 15;195(2):161-9
  23. Borroto-Escuela DO, Romero-Fernandez W, Tarakanov AO, Gómez-Soler M, Corrales F, Marcellino D, Narvaez M, Frankowska M, Flajolet M, Heintz N, Agnati LF, Ciruela F, Fuxe K. Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices. Biochem Biophys Res Commun. 2010 Nov 26;402(4):801-7.
  24. Díaz-Cabiale Z, Parrado C, Narváez M, Millón C, Puigcerver A, Fuxe K, Narváez JA. The Galanin N-terminal fragment (1-15) interacts with neuropeptide Y in central cardiovascular control: Involvement of the NPY Y2 receptor subtype. Regul Pept. 2010 Aug 9;163(1-3):130-6
  25. Borroto-Escuela DO, Correia PA, Perez Alea M, Narvaez M, Garriga P, Fuxe K, Ciruela F. Impaired M(3) muscarinic acetylcholine receptor signal transduction through blockade of binding of multiple proteins to its third intracellular loop. Cell Physiol Biochem. 2010;25(4-5):397-408
  26. Vela C, Diaz-Cabiale Z, Parrado C, Narvaez M, Covenas R, Narvaez JA. Involvement of oxytocin in the nucleus tractus solitarii on central cardiovascular control: interactions with glutamate. J Physiol Pharmacol. 2010 Feb;61(1):59-65.
  27. Borroto-Escuela DO, Marcellino D, Narvaez M, Flajolet M, Heintz N, Agnati L, Ciruela F, Fuxe K. A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R. Biochem Biophys Res Commun. 2010 Mar 26;394(1):222-7
  28. Borroto-Escuela DO, Narvaez M, Marcellino D, Parrado C, Narvaez JA, Tarakanov AO, Agnati LF, Díaz-Cabiale Z, Fuxe K. Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization. Biochem Biophys Res Commun. 2010 Mar 19;393(4):767-72.


Personal Profile

https://www.uma.es/departamento-de-fisiologia-humana-histologia-humana-anatomia-patologia-educion-fisica-y-deportiva/info/46099/manuel-alejandro-narvaez-pelaez/?set_language=en
https://www.researchgate.net/profile/Manuel-Narvaez-Pelaez
https://orcid.org/0000-0003-0922-4900
https://www.webofscience.com/wos/author/record/L-1887-2014
Web of Science ResearcherID: L-1887-2014

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