Dr. Yongchao Su

Massachusetts Institute of Technology, USA

Research Fellow

Email: ycsu@mit.edu

Qualifications

2011 Ph.D., Chemistry, Iowa State University, USA

2006 M.Sc.,  Physics, Chinese Academy of Sciences, China

2003 B.Sc., Chemistry, Huazhong University of Science & Technology, China

2003 B.A., English, Huazhong University of Science & Technology, China

Publications (selected)

1. Nishiyama, Y., Hou, G., Agarwal, V., Su, Y., & Ramamoorthy, A. (2022). Ultrafast magic angle spinning solid-state NMR spectroscopy: Advances in methodology and applications. Chemical reviews, 123(3), 918-988.
2. Li, M., Xu, W., & Su, Y. (2021). Solid-state NMR spectroscopy in pharmaceutical sciences. TrAC Trends in Analytical Chemistry, 135, 116152.
3. Davis Jr, D. A., Thakkar, R., Su, Y., Williams III, R. O., & Maniruzzaman, M. (2021). Selective laser sintering 3-dimensional printing as a single step process to prepare amorphous solid dispersion dosage forms for improved solubility and dissolution rate. Journal of pharmaceutical sciences, 110(4), 1432-1443.
4. Phyo, P., Zhao, X., Templeton, A. C., Xu, W., Cheung, J. K., & Su, Y. (2021). Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy. Advanced Drug Delivery Reviews, 174, 1-29.
5. Chen, Y., Ling, J., Li, M., Su, Y., Arte, K. S., Mutukuri, T. T., ... & Zhou, Q. T. (2021). Understanding the impact of protein–excipient interactions on physical stability of spray-dried protein solids. Molecular pharmaceutics, 18(7), 2657-2668.
6. Zhao, F., Zhang, D., Zhou, Q., Zhao, F., He, M., Yang, Z., ... & Zhou, X. (2020). Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis. EBioMedicine, 57.
7. Lu, X., Huang, C., Lowinger, M. B., Yang, F., Xu, W., Brown, C. D., ... & Su, Y. (2019). Molecular interactions in posaconazole amorphous solid dispersions from two-dimensional solid-state NMR spectroscopy. Molecular pharmaceutics, 16(6), 2579-2589.
8. Gelenter, M. D., Smith, K. J., Liao, S. Y., Mandala, V. S., Dregni, A. J., Lamm, M. S., ... & Hong, M. (2019). The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations. Nature structural & molecular biology, 26(7), 592-598.
9. Iadanza, M. G., Silvers, R., Boardman, J., Smith, H. I., Karamanos, T. K., Debelouchina, G. T., ... & Radford, S. E. (2018). The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism. Nature Communications, 9(1), 4517.
10. Ni, Q. Z., Markhasin, E., Can, T. V., Corzilius, B., Tan, K. O., Barnes, A. B., ... & Griffin, R. G. (2017). Peptide and protein dynamics and low-temperature/DNP magic angle spinning NMR. The Journal of Physical Chemistry B, 121(19), 4997-5006.
11. Nie, H., Su, Y., Zhang, M., Song, Y., Leone, A., Taylor, L. S., ... & Byrn, S. R. (2016). Solid-state spectroscopic investigation of molecular interactions between clofazimine and hypromellose phthalate in amorphous solid dispersions. Molecular pharmaceutics, 13(11), 3964-3975.
12. Y. Su, F. Hu and M. Hong, Paramagnetic Cu(II) for Probing Membrane Protein Structure and Function: Inhibition of the influenza M2 Proton Channel, J. Am. Chem. Soc., 2012, 134(20), 8693-8702 (2012)
13. S, Li* and Y. Su* (*corresponding authors) and M. Hong, Intra-molecular 1H-13C Distance Measurement in Uniformly 13C, 15N Labeled Peptide by Solid State NMR, Solid State Nucl. Magn. Reson. 45-46, 51-58 (2012)
14. Y. Su and M. Hong, “Conformational Disorder of Membrane Peptides Investigated from Solid-State NMR Linewidths and Lineshapes”, J. Phys. Chem. B. 115(36), 10758-10767 (2011)
15. M. Hong and Y. Su, “Structure and Dynamics of Cationic Membrane Peptides and Proteins: Insights from Solid-State NMR”, Protein Science, 20(4), 641-655 (2011)
16. Y. Su, A. J. Waring, P. Ruchala and M. Hong, “Solid-State NMR Study of β-hairpin Antimicrobial Protegrin Peptides in Lipopolysaccharide Incorporated Lipid Membranes: Mechanism of Gram Selectivity”, Biochemistry, 50(12), 2072-2083 (2010)
17. Y. Su, W. F. DeGrado and M. Hong, “Orientation, Dynamics and Lipid Interaction of an Antimicrobial Arylamide Investigated by 19F and 31P Solid-State NMR Spectroscopy”, J. Am. Chem. Soc. 132(26), 9197–9205 (2010)
18. T. Doherty*, Y. Su* (*equal contribution) and M. Hong, “High-Resolution Orientation and Depth of Insertion of the Voltage-Sensing S4 Helix of a Potassium Channel in Lipid Bilayers”, J. Mol. Biol. 401(4), 642-652 (2010)
19. Y. Su, A. J. Waring, P. Ruchala and M. Hong, “Membrane-Bound Dynamic Structure of an Arginine-Rich Cell-Penetrating Peptide, the Protein Transduction Domain of HIV TAT, from Solid-State NMR”, Biochemistry. 49 (29), 6009–6020 (2010)
20. S. Li, Y. Su, W. Luo and M. Hong, “Water-Protein Interactions of an Arginine-Rich Membrane Peptide in Lipid Bilayers Investigated by Solid-State Nuclear Magnetic Resonance Spectroscopy”, J. Phys. Chem. B. 114, 4063–4069 (2010)
21. Y. Su, T. Doherty, A. J. Waring, P. Ruchala and M. Hong, “Role of Arginine and Lysine Residues in the Translocation of a Cell-Penetrating Peptide from 13C, 31P and 19F Solid-State NMR”, Biochemistry, 48(21), 4587-4595 (2009).
22. Y. Su, R. Mani, T. Doherty, A. J. Waring and M. Hong, “Reversible Sheet – Turn Conformational Change of a Cell-Penetrating Peptide in Lipid Bilayers Studied by Solid-State NMR”, J. Mol. Biol. 381, 1133-1144 (2008).
23. Y. Su, R. Mani, and M. Hong, “Asymmetric Insertion of Membrane Proteins in Lipid Bilayers by Solid-State NMR Paramagnetic Relaxation Enhancement: a Cell-Penetrating Peptide Example”, J. Am. Chem. Soc. 130(27), 8856-8864 (2008).
24. S. Li, A. Zheng, Y. Su, H. Fang, W. Shen, Z. Yu, L. Chen and F. Deng, “Extra-Framework Aluminum Species in Hydrated Faujasite Zeolite as Investigated by Two-Dimensional Solid-State NMR Spectroscopy and Theoretical Calculations”, Phys. Chem. Chem. Phys. 12(15), 3895-3903 (2010).
25. S. Li, A. Zheng, Y. Su, H. Zhang, L. Chen, J. Yang, C. Ye, and F. Deng, “Brønsted/Lewis Acid Synergy in Dealuminated HY Zeolite: A Combined Solid-State NMR and Theoretical Calculation Study”, J. Am. Chem. Soc. 129(36), 11161-1117 (2007).
26. J. Wang, Y. Su, J. Xu, C. Ye and F. Deng, “Acid Sites and Oxidation Center in Molybdena Supported on Tin Oxide as Studied by Solid-State NMR Spectroscopy and Theoretical Calculation”, Phys. Chem. Chem. Phys. 8, 2378-2384 (2006).
27. W. Hu, Q. Luo, Y. Su, L. Chen, Y. Yue, C. Ye, and F. Deng, “Acid Sites in Mesoporous Al-SBA-15 Material as Revealed by Solid-State NMR Spectroscopy”, Microporous and Mesoporous Mater. 92, 22-30 (2006).
28. J. Xu, A. Zheng, J. Yang, Y. Su, J. Wang, D. Zeng, F. Deng, M. Zhang, and C. Ye, “Acidity of Mesoporous MoOx/ZrO2 and WOx/ZrO2 Materials: A Combined Solid-State NMR and Theoretical Calculation Study”, J. Phys. Chem. B. 110(22), 10662-10671 (2006).
29. A. Zheng, L. Chen, J. Yang, M. Zhang, Y. Su, Y. Yue, and F. Deng, “Combined DFT Theoretical Calculation and Solid-State NMR Studies of Al Substitution and Acid Sites in Zeolite H-MCM-22”, J. Phys. Chem. B. 109(51), 24273-24279 (2005).
30. W. Hu, Y. Su, L. Chen, Y. Yue, S. Li, and F. Deng, “The 27Al State in CeO2-γ-Al2O3 Mixed Oxides Determined by Solid-State NMR Spectroscopy”, Chinese J. Magn. Reson. 24(1), 17-25 (2007)
31. Y. Su, A. Zheng, S. Li, L. Chen, and F. Deng, “Quantum Chemical Calculation on 13C NMR Shifts of Small Drug Molecules”, Chinese J. Magn. Reson. 23(3), 293-301 (2006)

Profile Details

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