Dr. Daniel Sliva

Cancer Research Laboratory

Methodist Research Institute

Indiana University Health

Indianapolis, Indiana, USA

Department of Medicine

Indiana University School of Medicine

Indianapolis, Indiana, USA



1993 Ph.D., Charles University, Molecular Biology and Genetics

1988 M.Sc., Charles University, Biochemistry

1983 M.Sc.,University of Chemical Technology, Food and Biochemical Technology

Publications (Selected)

  1. Jiang J, Eliaz I, Sliva D. Synergistic effect of the modified citrus pectin Pectasol-CTM with BreastDefendTM and ProstaCaidTM in the suppression of invasive behavior of human breast and prostate cancer cells. Integr Cancer Ther. 2012 Apr 24. [Epub ahead of print]
  2. Jiang J, Thyagarajan-Sahu A, Krchňák V, Jedinak A, Sandusky GE, Sliva D. NAHA, a Novel Hydroxamic Acid-Derivative, Inhibits Growth and Angiogenesis of Breast Cancer In Vitro and In Vivo. PLoS One. 2012;7(3):e34283. Epub 2012 Mar 29.
  3. Jiang J, Loganathan J, Eliaz I, Terry C, Sandusky G, Sliva D. ProstaCaidTM inhibits tumor growth in a xenograft model of human prostate cancer. Int J Oncol. 2012; 40: 1339-44.
  4. Jiang J, Slivova V, Jedinak A, Sliva D. Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-kB/ AP-1 dependent- and independent- signaling. Clin Exp Metastasis. 2012; 29: 165-78.
  5. Kennedy EM, P'pool SJ, Jiang J, Sliva D, Minto RE. Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols. J Nat Prod. 2011; 74: 2332-7.
  6. Jiang J, Jedinak A, Sliva D. Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. Biochem Biophys Res Commun. 2011; 415: 325-9.
  7. Sliva D. Medicinal mushroom Phellinus linteus as an alternative cancer therapy (Review). Exp Ther Medicine 2010; 1: 407-411.
  8. Harvey K. A., Welch Z., Sliva D., Siddiqui R. A., Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation. Mol. Cell Biochem., 2010; 342: 7-19.
  9. Jedinak A, Dudhgaonkar S, Sliva D. Activated macrophages induce metastatic behavior of colon cancer cells. Immunobiology. 2010; 215: 242-9.
  10. Sliva D. Medicinal potential of Ganoderma lucidum. In: Applied Mycology, (CAB International, Eds.: M. Rai and P.D. Bridge), 2009, pp 173-196.
  11. Adamec J, Jannash A, Dudhgaonkar S, Jedinak A, Sedlak M, Sliva D. Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: Determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds. J Separation Sci. 2009; 32: 4052-8.
  12. Jiang J, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-B signaling. Int J Mol Med. 2008;21:577-84.
  13. Sliva D, and Srivastvava R: Regulation of NF-B function: target for drug development. In: Molecular Mechanisms Volume 1: Apoptosis, Cell Signaling, and Human Disease, (The Humana Press, Inc., Ed.: Srivastava R.), 2007, pp 239-261.
  14. Jiang J, Slivova V, Sliva D. Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-B signaling. Int J Oncol. 2006;29:695-703.
  15. Sliva D. Ganoderma lucidum in cancer research. Leukemia Res. 2006; 30: 767-8.
  16. Slivova V, Zaloga G, DeMichele SJ, Mukerji P, Huang YS, Siddiqui R, Harvey K, Valachovicova T, Sliva D. Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells. Nutr Cancer. 2005; 52: 65-72.
  17. Stanley G, Harvey K, Slivova V, Jiang J, Sliva D. Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF from prostate cancer cells. Biochem Biophys Res Commun. 2005; 330: 46-52.
  18. Sliva D. Soy isoflavones and the invasiveness of breast cancer. AgroFOOD industry hi-tech. 2005; 16: 40-1.
  19. Valachovicova T, Slivova V, Bergman H, Shuherk J, Sliva D. Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-B/AP-1 -dependent and -independent pathways. Int J Oncol. 2004; 25: 1389-96.
  20. Jiang J, Slivova V, Harvey K, Valachovicova T, Sliva D. Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-B signaling. Nutr Cancer 2004; 49: 209-16.
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