Dr. Zhiwei Hu

The OSU James Comprehensive Cancer Center, Department of Surgery, College of Medicine

The Ohio State University, USA

Associate Professor



1997 Ph.D., Tumor Immunobiology, Hunan Medical University, China

1994 M.Sc., Tumor Immunology, Jiangxi Medical College, China

1991 M.D., Medicine and Stomatology, Jiangxi Medical College, China

Publications (Selected)

  1. Zhiwei Hu*, Samira A. Brooks, Valérian Dormoy, Chia-Wen Hsu, Hsue-Yin Hsu, Liang-Tzung Lin, Thierry Massfelder, W. Kimryn Rathmell, Menghang Xia, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Dustin Brown, Kalan R Prudhomme, Annamaria Colacci, Roslida A. Hamid, Chiara Mondello, Jayadev Raju, Elizabeth Ryan, Jordan Woodrick, Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Hosni K. Salem, Leroy Lowe, Lasse Jensen, William H. Bisson, Nicole Kleinstreuer. (2015) Assessing the Carcinogenic Potential of Low Dose Exposures to Chemical Mixtures in the Environment: Focus on the Cancer Hallmark of Tumor Angiogenesis. Carcinogenesis. 2015 Jun;36 Suppl 1:S184-202. doi: 10.1093/carcin/bgv036.
  2. Zhiwei Hu*, Nancy Oleinick and Michael R Hamblin. (2014) Photodynamic Therapy as an Emerging Treatment Modality for Cancer and Non-Cancer Diseases. J Anal Bioanal Tech. S1: e001. doi: 10.4172/2155-9872. S1-e001.
  3. Zhiwei Hu. (2013) Overcome the impairment of NK cells for Icon and antibody immunotherapy of cancer. Journal of Immune Based Therapy, Vaccines and Antimicrobials. 2(1): 1-8.
  4. Zhiwei Hu. (2012) Dual targeting of tumor neovasculature and tumor cells by tissue factor-targeted photodynamic therapy. Journal of Analytical & Bioanalytical Techniques. 3(4) e105.
  5. Jijun Cheng, Jie Xu, Jinzhong Duanmu, Han Zhou, Carmen J. Booth and Zhiwei Hu. (2011) Effective treatment of human lung cancer by targeting tissue factor with a factor VII-targeted photodynamic therapy. Current Cancer Drug Targets. 11(9): 1069-1081.
  6. Jinzhong Duanmu, Jijun Cheng, Jie Xu, Carmen J. Booth and Zhiwei Hu(2011). Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy. British Journal of Cancer. 104(9): 1401-1409.
  7. Zhiwei Hu, Benqiang Rao, Shimin Chen and Jinzhong Duanmu. (2011) Selective and effective killing of angiogenic vascular endothelial cells and cancer cells by targeting tissue factor using a factor VII-targeted photodynamic therapy for breast cancer. Breast Cancer Research and Treatment. 126(3): 589-600.
  8. Zhiwei Hu and Jing Li (2010). Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. BMC Immunology. 2010, 11(1):49. This article has been labeled as “Highly Accessed” by the Journal and is publicly available at
  9. Zhiwei Hu, Benqiang Rao, Shimin Chen and Jinzhong Duanmu. (2010) Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivo in mice. BMC Cancer. 2010, 10:235. This article is publicly available at
  10. Emiliano Cocco, Zhiwei Hu, Christine E. Richter, Stefania Bellone, Francesca Casagrande, Marta Bellone, Paola Todeschini, Graciela Krikun, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford, Sergio Pecorelli, Charles J. Lockwood, and Alessandro D. Santin. (2010) hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma. British Journal of Cancer. 103(6): 812-9.
  11. Graciela Krikun, Zhiwei Hu, Kevin Osteen, Kaylon Tran-Brunner, Frederick Schatz, Hugh S. Taylor, Paolo Toti, Felice Arcuri, William Konigsberg, Alan Garen, Carmen J. Booth, and Charles J. Lockwood. (2010) Targeting Tissue Factor with the Immunoconjugate “Icon” Leads To the Regression of Endometriosis Through Destruction of Aberrant Blood Vessels. American Journal of Pathology 176(2): 1050-1056.
  12. Fang Lu, Zhiwei Hu, John Sinard, Alan Garen, and Ron A Adelman. (2009) Factor VII–verteporfin for Targeted Photodynamic Therapy in a Rat Model of Choroidal Neovascularization. Investigative Ophthalmology & Visual Science. 50(8): 3890-6.
  13. Joseph S. Palumbo, Kathryn E. Talmage, Jessica V. Massari, Christine M. La Jeunesse, Matthew J. Flick, Keith W. Kombrinck, Zhiwei Hu, Kelley A. Barney, and Jay L. Degen. (2007) Tumor cell-expressed tissue factor and circulating coagulation factors cooperatively increase metastatic potential through natural killer cell-dependent and cell-independent mechanisms. Blood. 110(1): 133-41.
  14. Tongalp H. Tezel, Ewa Bodek, Kenan Sönmez, Sankar Kaliappan, Henry J. Kaplan, Zhiwei Hu, Alan Garen. (2007) Targeting tissue factor for immunotherapy of choroidal neovascularization by intravitreal injection of factor VII-IgG1 Fc chimeric antibody. Ocular Immunology and Inflammation. 15: 3-10.
  15. Yucheng Tang, Per Borgstrom, Jonathan Maynard, Zhiwei Hu, Alan Garen, and Albert Deisseroth. (2007) Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells. Cancer Gene Therapy. 14: 346-353.
  16. Puran S. Bora, Zhiwei Hu, Tongalp H. Tezel, Jeong- Hyeon Sohn, Shin Goo Kang, Jose M. Cruz, Nalini S. Bora, Alan Garen and Henry J. Kaplan. (2003) Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc. Natl. Acad. Sci. USA. 100: 2679-2684.
  17. Zhiwei Hu. Antigen-driven stimulation of B-lymphocytes in vitro. In O’Brian, P.M and Aitken, R., ed., Methods in Molecular Biology, Volume 178: Antibody Phage Display: Methods and Protocols. The Humana Press Inc., New Jersey, USA. 2002; p 113-119.
  18. Zhiwei Hu and Alan Garen. (2001) Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer. Proc. Natl. Acad. Sci. USA. 98: 12180-12185.
  19. Zhiwei Hu and Alan Garen. (2000) Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy. Proc. Natl. Acad. Sci. USA. 97: 9221-9225.
  20. Zhiwei Hu, Ying Sun and Alan Garen. (1999) Targeting tumor vasculature endothelial cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft model. Proc. Natl. Acad. Sci. USA. 96: 8161-8166.

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