Dr. Lbachir BenMohamed

Cellular and Molecular Immunology Hewitt Hall

University of California, Irvine, USA



1997  Ph.D., Immunology, Pasteur Institute & Paris VII University, France

1990  M.S., Molecular Biology and Biochemistry, Paris VI University, France

1984  B.Sc., Experimental Biology, Morocco

Publications (Selected)

  1. Fidock DA, Gras-Masse H, Lepers JP, Brahimi K, BenMohamed L, Mellouk S, Guerin-Marchand C, Londono A, Raharimalala L & Meis JF. Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants. The Journal of Immunology. 1994. 153(1): 190-204.
  2. Bottius E, BenMohamed L, Brahimi K, Gras H, Lepers JP, Raharimalala L, Aikawa M, Meis J, Slierendregt B, Tartar A, Thomas A & Druilhe P. A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes. The Journal of Immunology. 1996. 156(8): 2874-84.
  3. BenMohamed L, Gras-Masse H, Tartar A, Daubersies P, Brahimi K, Bossus M, Thomas A & Druilhe P. Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees.European Journal of Immunology. 1997. 27(5): 1242-53.
  4. Bossus M, BenMohamed L, Londono A, Barbier B, Tartar A, Druilhe P & Gras-Masse H. Improved detection of human antibodies to a Plasmodium antigen using a peptide modified with Aib residues.Journal of Peptide Science. 1997. 3(1): 47-53.
  5. Daubersies P, Thomas AW, Millet P, Brahimi K, Langermans JA, Ollomo B, BenMohamed L, Slierendregt B, Eling W, Van Belkum A, Dubreuil G, Meis JF, Guérin-Marchand C, Cayphas S, Cohen J, Gras-Masse H, Druilhe P. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nature Medicine. 2000. 6(11): 1258-63.
  6. BenMohamed L, Krishnan R, Longmate J, Auge C, Low L, Primus J, Diamond DJ. Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response. Human Immunology. 2000. 61(8): 764-79.
  7. BenMohamed L, Thomas A, Bossus M, Brahimi K, Wubben J, Gras-Masse H, Druilhe P. High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules. Vaccine. 2000. 18(25): 2843-55.
  8. Brahimi K, Badell E, Sauzet JP, BenMohamed L, Daubersies P, Guérin-Marchand C, Snounou G,Druilhe P. Human antibodies against Plasmodium falciparum liver-stage antigen 3 cross-react with Plasmodium yoelii preerythrocytic-stage epitopes and inhibit sporozoite invasion in vitro and in vivo.Infection and Immunity. 2001. 69(6): 3845-52.
  9. Perng GC, Maguen B, Jin L, Mott KR, Kurylo J, BenMohamed L, Yukht A, Osorio N, Nesburn AB,Henderson G, Inman M, Jones C, Wechsler SL. A novel herpes simplex virus type 1 transcript (ALRNA)antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits. Journal of Virology. 2002. 76(16): 8003-10.
  10. BenMohamed L, Wechsler SL, Nesburn AB. Lipopeptide vaccines--yesterday, today, and tomorrow.Lancet Infectious Diseases. 2002. 2(7): 425-31.
  11. BenMohamed L, Belkaid Y, Loing E, Brahimi K, Gras-Masse H, Druilhe P. Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant. European Journal of Immunology. 2002. 32(8): 2274-81.
  12. BenMohamed L, Krishnan R, Auge C, Primus JF, Diamond DJ. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology. 2002. 106(1): 113-21.
  13. Vichier-Guerre S, Lo-Man R, BenMohamed L, Dériaud E, Kovats S, Leclerc C, Bay S. Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use. Journal of Peptide Research. 2003. 62(3): 117-24.
  14. BenMohamed L, Bertrand G, McNamara CD, Gras-Masse H, Hammer J, Wechsler SL & Nesburn AB. Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity. Journal of Virology. 2003. 77(17): 9463-73.
  15. Zhu X, Ramos TV, Gras-Masse H, Kaplan BE & BenMohamed L. Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Tolllike receptor-2 pathway and trigger a Th1-dependent protective immunity. European Journal of Immunology. 2004. 4(11): 3102-14.
  16. Lo-Man R, Vichier-Guerre S, Perraut R, Dériaud E, Huteau V, BenMohamed L, Diop OM, Livingston PO, Bay S & Leclerc C. A fully synthetic therapeutic vaccine candidate targeting carcinomaassociated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates. Cancer Research. 2004. 64(14): 4987-94.
  17. BenMohamed L, Thomas A & Druilhe P. Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides. Infection and Immunity. 2004. 72(8): 4376-84.
  18. Peng W, Henderson G, Inman M, BenMohamed L, Perng GC, Wechsler SL & Jones C. The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice. Journal of Virology. 2005. 79(10): 6162-71.
  19. Nesburn AB, Ramos TV, Zhu X, Asgarzadeh H, Nguyen V & BenMohamed L. Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant. Vaccine.2005. 23(7): 873-83.
  20. Zhang X, Issagholian A, Berg EA, Fishman JB, Nesburn AB & BenMohamed L. Th-cytotoxic Tlymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection. Journal of Virology.2005. 79(24): 15289-301.

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