Prof. Rafat Ali Siddiqui

Methodist Research Institute

Indiana University School of Medicine, USA

Professor

Email: rsiddiqu@iuhealth.org, rasiddiq@iupui.edu

Qualifications

1988  Ph.D., Biochemistry, Australian National University, Australia

1980  M.Sc., Biochemistry, University of Karachi, Pakistan

1978  B.Sc., Biochemistry, University of Karachi, Pakistan

Publications

1. Harvey K., Walker C., Xu Z., Whitley P. and Siddiqui R. (2012), Trans Fatty Acids: Induction of a Pro-inflammatory Phenotype in Endothelial Cells, Lipids, 47, 647-657.
2. Van Horn J., Altenburg J., Harvey H., Xu Z., Kovacs R. and Siddiqui, R. (2012), Attenuation of Niacin-Induced Prostaglandin D2Generation by Omega-3 Fatty Acids in THP-1 Macrophages and Langerhans Dendritic Cells, Journal of Inflammation Research, 5, 37–50.
3. Siddiqui R., Harvey K., Xu Z., Bammerlin E., Walker C. and Altenburg J. (2011), Docosahexaenoic acid: A Natural Powerful Adjuvant that Improves Efficacy for Anticancer Treatment with No Adverse Effects, BioFactors, 37, 399-412.
4. Altenburg J., Bieberich A., Terry C., Harvey H., Van Horn J., Xu Z., Davisson V. and Siddiqui R. (2011), A Synergistic Antiproliferation Effect of Curcumin and Docosahexaenoic Acid in SK-BR-3 Breast Cancer Cells: Unique Signaling Not Explained by the Effect of Either Compound Alone, BMC-Cancer, 11, 149.
5. Altenburg J., Harvey K., McCray S., Xu Z. and Siddiqui, R. (2011),A Novel 2,6-Diisopropylphenyl–Docosahexaenoamide Conjugate Induces Apoptosis in T Cell Acute Lymphoblastic Leukemia Cell Lines, Biochemical and Biophysical Research Communications, 411, 427–432.
6. Antalis C., Uchida A., Buhman K. and Siddiqui R. (2011), Migration of MDA-MB-231 Breast Cancer Cells Depends on the Availability of Exogenous Lipids and Cholesterol Esterification, Clinical and Experimental Metastasis, 28, 733-741.
7. Harvey K., Walker C., Xu Z., Whitley P., Pavlina T., Hise M., Zaloga G. and Siddiqui R. (2010), Oleic Acid Inhibits Stearic Acid-Induced Inhibition of Cell Growth and Pro-Inflammatory Responses in Human Aortic Endothelial Cells, Journal of Lipid Research, 51, 3470-3480.
8. Harvey K., Welch Z., Sliva D. and Siddiqui R. (2010), Role of Rho Kinase in Spingosine 1-Phosphate-Mediated Endothelial and Smooth Muscle Cell Migration and Differentiation, Molecular and Cellular Biochemistry, 342, 7-19.
9. Harvey K., Walker C., Pavlina T., Xu Z., Zaloga G. and Siddiqui R. (2010), Long-Chain Saturated Fatty Acids Induce Pro-Inflammatory Responses and Impact Endothelial Cell Growth, Clinical Nutrition, 29, 492-500.
10. Antalis C., Arnold T., Rasool T., Lee B., Buhman K. and SiddiquiR. (2010), High ACAT1 Expression in Estrogen Receptor Negative Basal-Like Breast Cancer Cells is Associated with LDL-Induced Proliferation, Breast Cancer Research and Treatment, 122, 661-670.
11. Harvey K., Xu Z., Whitley P., Davisson V. and Siddiqui R. (2010), Characterization of Anticancer Properties of 2, 6 Diisopropylphenol- Docosahexaenoate and Analogues in Breast Cancer Cells, Bioorganic and Medicinal Chemistry, 18, 1866-1874.
12. Xu,Z., Harvey K., Pavlina T., Dutot G., Zaloga G. and Siddiqui R.(2010), An Improved Method for Determining Medium- and Long-Chain FAMEs Using Gas Chromatography, Lipids, 45, 199-208.
13. Altenburg J. and Siddiqui R. (2010), Docosahexaenoic Acid Downregulates Interferon Gamma-Induced Expression of CXCL16 in Human Aortic Smooth Muscle Cells, Biochemical and Biophysical Research Communications, 391, 609–614.
14. Minner D., Rauch P., Siegel A., Stelzer J., Ka´s, J., Sprowl G., Harvey K., Siddiqui R., Atkinson S. and Nauman C. (2009), Tuning Cellular Mechano-Response Using Biomembrane-Mimicking Substrates of Adjustable Fluidity, Biophysical Journal, 96(3), 521.
15. Siddiqui R., Harvey K., Ruzmetov N., Miller S. and Zaloga G. (2009), Omega-3 Fatty Acids Prevent Whereas Trans Fatty Acids Induce Vascular Inflammation and Sudden Cardiac Death,British Journal of Nutrition, 102, 1811-1819.
16. Siddiqui R., Hassan S., Harvey K., Das T., Mukerji P. and DeMichele S. (2009), Attenuation of Cancer Cachexia by Curcumin C3 Complex in MAC-16 Tumor-bearing Mice, British Journal of Nutrition, 102, 967-975.
17. Altenburg J. and Siddiqui R. (2009), Omega-3 Polyunsaturated Fatty Acids Down Modulate CXCR4 Expression and Function in MDA-MB-231 Breast Cancer Cells, Molecular Cancer Research, 7(7), 1013–1020.
18. Antalis C., Arnold T., Lee B., Buhman K. and Siddiqui R. (2009), Docosahexaenoic Acid Is a Substrate for ACAT1 and Inhibits Cholesteryl Ester Formation from Oleic Acid in MCF-10A Cells, Prostaglandins Leukotrienes and Essential Fatty Acids, 80, 165-171.
19. Harvey K., Arnold T., Rasool T., Antalis C., Miller S. and Siddiqui R. (2008), Trans Fatty Acids Induce Pro-inflammatory Responses and Endothelial Cell Dysfunction, British Journal of Nutrition, 99, 723-731.
20. Siddiqui R., Harvey K. and Stillwell W. (2008), Anticancer Properties of Oxidation Products of Docosahexaenoic Acid, Chemistry and Physics of Lipids, 153, 47-56.
21. Siddiqui R., Harvey K., Miller S. and Zaloga G. (2008), Impact of Omega-3 and Trans Fatty Acids on Vascular Remodeling: Opposing Roles in Cardiovascular Health, Current Enzyme Inhibition, 4, 60-72.
22. Friedman A., Siddiqui R. and Watkins B. (2008), Acute Rise of Omega-3 Polyunsaturated Fatty Acids During Hemodialysis Treatment, Journal of Renal Nutrition, 18, 301-303.
23. Siddiqui R., Harvey K. and Zaloga G. (2008), Modulation of Enzymatic Activities by n-3 Polyunsaturated Fatty Acids to Support Cardiovascular Health. Journal of Nutritional Biochemistry, 19, 417-437.

Profile Details

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