Dr. Yuk Yin Sham

Center for Drug Design, Senior Graduate faculty, Bioinformatics and Computational Biology Program

Assistant Professor and Assistant Director

Minnesota Supercomputing Institute

University of Minnesota, USA

Associate Professor

Email: shamx002@umn.edu

Qualifications

1999 Ph.D., Department of Chemistry, University of Southern California, USA

1993 B.Sc., Department of Chemistry, Florida International University, USA

Publications (selected)

1. Bogdan M, B., Rupak, K., Trae, H., Chuanqi, S., Anna, C., Taylor, K., Yuk Yin, S., Robert, B., Jeffrey D, M., & Woo Shik, S. (2024) Development of non-β-Lactam covalent allosteric inhibitors targeting PBP2a in Methicillin-Resistant Staphylococcus aureus., bioRxiv : the preprint server for biology
2. Bogdan M., B., Trae, H., Noah, A., Yuk Yin, S., Belinda, W., & Woo Shik, S. (2024) Carbapenem-induced Β-Lactamase-isoform Expression Trends in Acinetobacter Baumannii, SCIENTIFIC REPORTS, 14.1
3. K. Iall, S., Alexandru, P., Shelby, A., David, K., Ling, L., James, H., Walter, S., Yuk, S., Lorena, B., & Mark, D. (2024) Proteomic Analysis in Conjunction with Peptide Libraries and Bioinformatic Analysis Yields New Insights into the Specificity of Protein Prenylation and Its Role in Disease, JOURNAL OF PEPTIDE SCIENCE, 30
4. Garrett L., S., Emily R., H., You, W., Safwan, D., Holly A., P., Gavin W., P., Andrea M., S., Ethan R., L., Taylor S., K., Yuk Y., S., James L., H., Lorena S., B., Walter K., S., & Mark D., D. (2024) Library Screening, in Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences As Substrates for Protein Farnesyltransferase, International journal of molecular sciences, 25.10
5. Bakar A., H., Jozafina, M., Meka, T., Ramesh, K., Yuk Y., S., Patrick A., F., & Erika A., T. (2024) In Vitro and in Silico Explorations of the Protein Conformational Changes of Corynebacterium Glutamicum MshA, a Model Retaining GT-B Glycosyltransferase, BIOCHEMISTRY, 63.7: 939-951.
6. Bhavani S., S., Maria, R., Seth, M., Jean Pierre, P., Megin E., N., Masato, S., Cheng, J., Wei-Jye, L., Kevin A., K., Pedro, R., Rachel, M., Cheryl, C., Giada, C., Paola, P., Loredana, R., Megan, B., Emilyn, A., Yuk Y., S., Andrea, F., Stephen R., S., & Alessandro, B. (2023) Targeted and Selective Knockout of the TLQP-21 Neuropeptide Unmasks Its Unique Role in Energy Homeostasis., Molecular metabolism, 76: 101781-101781.
7. Trae, H., Bogdan M., B., Chuanqi, S., Noah, A., Belinda, W., Yuk Yin, S., & Woo Shik, S. (2023) A Novel Strategy to Characterize the Pattern of Β-Lactam Antibiotic-Induced Drug Resistance in Acinetobacter Baumannii., Scientific reports, 13.1
8. Pedro, R., Lauren J., L., Jean Pierre, P., Hailey A., B., Natalie G., C., Emilie I., A., Maggie M., C., Maria, R., Yuk Y., S., John D., M., & Alessandro, B. (2023) Functional Profiling of the G Protein-Coupled Receptor C3aR1 Reveals Ligand-Mediated Biased Agonism, The Journal of biological chemistry, 300.1: 105549.
9. James B., T., Bogdan M., B., Adam, P., Woo Shik, S., Ramaiah, M., Yuk Yin, S., & Hazel M., H. (2023) Characterization of a Novel Inhibitor for the New Delhi Metallo-Β-lactamase-4: Implications for Drug Design and Combating Bacterial Drug Resistance., Journal of Biological Chemistry, 299.9
10. Zhengming, X., Elisabet Ampudia, M., G. Elizabeth, P., Susan K., R., David A., L., Yuk Y., S., Christopher L., M., & Michael R., O. (2023) Supplementary Legend from CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy, openalex
11. Bhavani S., S., Megin E., N., Pedro, R., Jean Pierre, P., Vinayak, G., Maria, R., Yuk Y., S., Stephen R., S., & Alessandro, B. (2023) The molecular identity of the TLQP-21 peptide receptor (vol 78, pg 133, 2021), Cellular and Molecular Life Sciences, 80.3
12. Chastity L., H., Sara J., P., Ingrid R., A., Vasudeva, D., Ramaiah, M., Yuk, S., & Timothy D., O. (2023) Eliminating Cardiotoxicity in Alpha1-adrenergic Receptor Antagonists, HYPERTENSION, 80
13. Jozafina, M., Bakar A., H., Joy M., C., Carlos A., R., Nadiya, J., Angelika, R., Kaelan R., P., Colleen D., C., Ramaiah, M., Yuk Y., S., & Erika A., T. (2022) Discovery of First-in-class Nanomolar Inhibitors of Heptosyltransferase I Reveals a New Aminoglycoside Target and Potential Alternative Mechanism of Action., Scientific reports, 12.1
14. Bakar A., H., Zhiqi A., L., Jozafina, M., Mia S., K., Meka, T., Yuk Y., S., & Erika A., T. (2022) Kinetic Characterization and Computational Modeling of Escherichia Coli Heptosyltransferase II: Exploring the Role of Protein Dynamics in Catalysis for GT-B Glycosyltransferase., Biochemistry, 61.15: 1572-1584.
15. Jozafina, M., Vasudeva R., D., Kaelan R., P., Ingrid Rodriguez, A., Timothy, O., Ramaiah, M., Erika A., T., & Yuk Y., S. (2022) Facile and Adaptable Synthesis of a Prazosin Analogue Library: Bringing Medicinal Chemistry into the Undergraduate Curriculum, Journal of Chemical Education, 99.3: 1428-1434.
16. Bhavani S., S., Megin E., N., Pedro, R., Jean Pierre, P., Vinayak, G., Maria, R., Yuk Y., S., Stephen R., S., & Alessandro, B. (2021) The Molecular Identity of the TLQP-21 Peptide Receptor, Experientia, 78.23: 7133-7144.
17. Ampudia-Mesias , E., Puerta-Martinez , F., Bridges , M., Zellmer , D., Janeiro , A., Strokes , M., Sham  Yuk, Y., Taher , A., Castro  Maria, G., Moertel  Christopher, L., Pluhar  G., E., & Olin  Michael, R. (2021) CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway, Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18.3: 1980-1994.
18. Carlos A., R., Megin E., N., Jozafina, M., Bakar A., H., Frank J., T., Ramaiah, M., Jiali, G., Erika A., T., & Yuk Y., S. (2021) Conserved Conformational Hierarchy Across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily As Determined from Microsecond Molecular Dynamics, International journal of molecular sciences, 22.9: 4619-4619.
19. Bakar A., H., Jozafina, M., Carlos Andres, R., Yuk Yin, S., & Erika A., T. (2021) Ligand-Induced Conformational and Dynamical Changes in a GT-B Glycosyltransferase: Molecular Dynamics Simulations of Heptosyltransferase I Complexes, Journal of Chemical Information and Modeling, 62.2: 324-339.
20. Woo Shik, S., Megin E., N., Alexander, B., Isabella R., J., Michael W., C., Ramaiah, M., & Yuk Yin, S. (2021) Fragment‐based Screening and Hit‐based Substructure Search: Rapid Discovery of 8‐hydroxyquinoline‐7‐carboxylic Acid As a Low‐cytotoxic, Nanomolar Metallo Β‐lactamase Inhibitor, Chemical biology & drug design, 98.4: 481-492.

Profile Details:

https://experts.umn.edu/en/persons/yuk-sham