Prof. Jacques E. Nör
University of Michigan, USA
Email: jenor@umich.edu
Qualifications
2001 Ph.D., Cancer Cell Biology, Dental School, University of Michigan
1994 M.Sc., Pediatric Dentistry, Dental School, University of Michigan
Publications (Selected)
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Dubey N, Ribeiro JS, Zhang Z, Xu J, Ferreira JA, Qu L, Mei L, Fenno JC, Schwendeman A, Schwendeman SP, Nör JE, Bottino MC. Gelatin methacryloyl hydrogel as an injectable scaffold with multi-therapeutic effects to promote antimicrobial disinfection and angiogenesis for regenerative endodontics. J Mater Chem B. 2023 May 3;11(17):3823-3835. doi: 10.1039/d2tb02788g. PubMed PMID: 36946228; PubMed Central PMCID: PMC10160005.
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Kim Y, Park HJ, Kim MK, Kim YI, Kim HJ, Bae SK, Nör JE, Bae MK. Naringenin stimulates osteogenic/odontogenic differentiation and migration of human dental pulp stem cells. J Dent Sci. 2023 Apr;18(2):577-585. doi: 10.1016/j.jds.2022.08.029. Epub 2022 Sep 16. PubMed PMID: 37021242; PubMed Central PMCID: PMC10068380.
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Rodriguez-Ramirez C, Zhang Z, Warner KA, Herzog AE, Mantesso A, Zhang Z, Yoon E, Wang S, Wicha MS, Nör JE. p53 Inhibits Bmi-1-driven Self-Renewal and Defines Salivary Gland Cancer Stemness. Clin Cancer Res. 2022 Nov 1;28(21):4757-4770. doi: 10.1158/1078-0432.CCR-22-1357. PubMed PMID: 36048559; PubMed Central PMCID: PMC9633396.
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Mantesso A, Zhang Z, Warner KA, Herzog AE, Pulianmackal AJ, Nör JE. Pulpbow: A Method to Study the Vasculogenic Potential of Mesenchymal Stem Cells from the Dental Pulp. Cells. 2021 Oct 20;10(11). doi: 10.3390/cells10112804. PubMed PMID: 34831027; PubMed Central PMCID: PMC8616523.
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Magno Guimarães D, deLucas da Silva Almeida F, Moraes Castilho R, Eduardo Nor J, Daumas Nunes F. DNA methyltransferase expression is associated with cell proliferation in salivary mucoepidermoid carcinoma. J Oral Pathol Med. 2020 Nov;49(10):1053-1060. doi: 10.1111/jop.13092. Epub 2020 Aug 19. PubMed PMID: 32740989.
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Nakashima M, Iohara K, Bottino MC, Fouad AF, Nör JE, Huang GT. Animal Models for Stem Cell-Based Pulp Regeneration: Foundation for Human Clinical Applications. Tissue Eng Part B Rev. 2019 Apr;25(2):100-113. doi: 10.1089/ten.TEB.2018.0194. Epub 2019 Jan 9. Review. PubMed PMID: 30284967; PubMed Central PMCID: PMC6486672.
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Wagner VP, Martins MD, Martins MAT, Almeida LO, Warner KA, Nör JE, Squarize CH, Castilho RM. Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas. Sci Rep. 2018 Feb 1;8(1):2065. doi: 10.1038/s41598-018-20345-w. PubMed PMID: 29391537; PubMed Central PMCID: PMC5794736.
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Almeida LO, Guimarães DM, Martins MD, Martins MAT, Warner KA, Nör JE, Castilho RM, Squarize CH. Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence. Stem Cell Res. 2017 May;21:94-105. doi: 10.1016/j.scr.2017.04.003. Epub 2017 Apr 8. PubMed PMID: 28426972; PubMed Central PMCID: PMC7071815.
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Wagner VP, Martins MA, Martins MD, Warner KA, Webber LP, Squarize CH, Nör JE, Castilho RM. Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis. Oncotarget. 2016 Nov 8;7(45):73032-73044. doi: 10.18632/oncotarget.12195. PubMed PMID: 27682876; PubMed Central PMCID: PMC5341961.
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Finkel KA, Warner KA, Kerk S, Bradford CR, McLean SA, Prince ME, Zhong H, Hurt EM, Hollingsworth RE, Wicha MS, Tice DA, Nör JE. IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence. Neoplasia. 2016 May;18(5):273-281. doi: 10.1016/j.neo.2016.03.004. Epub 2016 Apr 15. PubMed PMID: 27237319; PubMed Central PMCID: PMC4887598.
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Conde CM, Demarco FF, Casagrande L, Alcazar JC, Nör JE, Tarquinio SB. Influence of poly-L-lactic acid scaffold's pore size on the proliferation and differentiation of dental pulp stem cells. Braz Dent J. 2015 Mar-Apr;26(2):93-8. doi: 10.1590/0103-6440201300032. Epub 2015 Apr 1. PubMed PMID: 25831096.
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Kim JW, Choi H, Jeong BC, Oh SH, Hur SW, Lee BN, Kim SH, Nör JE, Koh JT, Hwang YC. Transcriptional factor ATF6 is involved in odontoblastic differentiation. J Dent Res. 2014 May;93(5):483-9. doi: 10.1177/0022034514525199. Epub 2014 Feb 25. PubMed PMID: 24570149; PubMed Central PMCID: PMC6728569.
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Piva E, Silva AF, Nör JE. Functionalized scaffolds to control dental pulp stem cell fate. J Endod. 2014 Apr;40(4 Suppl):S33-40. doi: 10.1016/j.joen.2014.01.013. Review. PubMed PMID: 24698691; PubMed Central PMCID: PMC4034046.
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Zeitlin BD, Nör JE. Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule. Curr Top Microbiol Immunol 348:115-37, 2011.
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Krishnamurthy S, Nör JE.Head and neck cancer stem cells.J Dent Res2011 Sep 20. [Epub ahead of print]
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Wang J, Chen J, Zhang K, Zhao Y, Nör JE, Wu J. TGF-β1 regulates the invasive and metastatic potential of mucoepidermoid carcinoma cells.J Oral Pathol Med. 2011 Jun 21. [Epub ahead of print]
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Tarquinio S, Zhang Z, Neiva K, Polverini PJ, Nör JE. Endothelial cell Bcl-2 and lymph node metastasis in patients with oral squamous cell carcinoma.J Oral Pathol Med2011 Sep 21. [Epub ahead of print]
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Campos M, Neiva K, Meyers K, Krishnamurthy S, Nör JE.Endothelial derived factors inhibit anoikis of head and neck cancer stem cells.Oral Oncol2011 Oct 17. [Epub ahead of print].
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Zhang Z, Sant’ana M, Nör JE.The biology of head and neck cancer stem cells. Oral Oncol(In press).
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Conde MC, Nedel F, Campos VF, Smith AJ, Nör JE, Demarco FF, Tarquinio S.Odontoblastic RNA Stability in Different temperature based protocols for Tooth Storage. Int Endod J(In press).
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Chokechanachaisakul U, Kaneko T, Yamanaka Y, Kaneko R, Katsube K, Kobayashi H, Nör JE, Okiji T, Suda H. Gene expression analysis of resident macrophages in lipopolysaccharide-stimulated rat molar pulp. J Endod 37:1258-63, 2011.
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Casagrande L, Cordeiro MM, Nör SA, Nör JE.Dental Pulp Stem Cells in Regenerative Dentistry. Odontology 99:1-7, 2011.
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Kaneko T, Okiji T, Kaneko R, Suda H, Nör JE. Laser-capture microdissection for Factor VIII-expressing endothelial cells in cancer tissues. Methods Mol Biol 755:395-403, 2011.
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Sakai VT, Cordeiro MM, Dong Z, Zhang Z, Zeitlin BD, Nör JE.Tooth Slice/Scaffold Model of Dental Pulp Tissue Engineering. Adv Dent Res 23:325-332, 2011.
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Kim JK, Baker J, Nör JE, Hill EE. mTor Plays an Important Role in Odontoblast Differentiation. J Endod 37:1081-1085, 2011.
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Demarco FF, Conde MCM, Cavalcanti B, Casagrande L, Sakai V, Nör JE.Dental pulp tissue engineering. Braz Dent J 22:3-13, 2011.
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Cavalcanti BN, Campos MS, Nör JE. Stem cells in health and disease. Rev Assoc Paul Cirdent 65:71-4, 2011.
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ChokechanachaisakulU, KanekoT, OkijiT, KanekoR, Suda H, Nör JE. Laser Capture Microdissection in Dentistry. Int J Dent 2011 Jan 13. [Epub ahead of print]
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Morelli T, Neiva R, Nevins ML, McGuire MK, Scheyer ET, Oh TJ, Braun TM, Nör JE, Bates D, Giannobile WV. Angiogenic Markers and Healing of Living Cellular Constructs.J Dent Res 90:456-62, 2011.
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Hegen A, Blois A, Tiron CE, Hellesøy M, Micklem DR, Nör JE, Akslen LA, Lorens JB. Efficientin vivovascularization of tissue engineering scaffolds. J Tissue Engin Regen Med5(4):e52-62, 2011.
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Rosa V, Botero TM, Nör JE. Regenerative endodontics in light of the stem cell paradigm. Int Dent J 61 (Suppl.1):23-28, 2011.
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Nedel F, Soki FN, Conde MC, Zeitlin BD, Tarquinio SB, Nör JE, Seixas FK, Demarco FF. Comparative analysis of two colorimetric assays in dental pulp cell density. Int Endod J44:59-64, 2011.
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Zhang R, Cooper P, Smith G, Nör JE, Smith AJ. Angiogenic activity of dentin matrix components”. J Endod 37:26-30, 2011.
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Telles PD, Machado MA, Sakai VT, Nör JE.Pulp tissue from primary teeth: new source of stem cells. J Appl Oral Sci 19:189-94, 2011.
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KrishnamurthyS, DongZ, VodopyanovD, ImaiA, HelmanJI, PrinceME, WichaMS, Nör JE. Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 70:9969-9978, 2010.
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Zhang Z, Neiva K, Lingen MW, Ellis LM, Nör JE. VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Diff 17:499-512, 2010.
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Zeitlin BD, Spalding AC, Campos MS, Ashimori N, Dong Z, Wang S, Lawrence TS, Nör JE. Metronomic small molecule inhibitor of Bcl-2 is anti-angiogenic and potentiates the anti-tumor effect of ionizing radiation. Int J Radia Oncol 78:879-887, 2010(Highlights section).
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Giordano RJ, Cardó-Vila M, Salameh A, Anobom CD, Zeitlin BD, Hawke DH, Valente AP, Almeida FC, Nör JE, Sidman RL, Pasqualini R, Arap W.From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway. Proc Natl Acad Sci USA 107:5112-5117, 2010.
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Casagrande L, Demarco F, Zhang Z, Araujo FB, Shi S, Nör JE. Dentin-derived BMP2 and odontoblastic differentiation of SHED. J Dent Res 89:603-608, 2010 (Journal Cover).
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Sakai VT, Zhang Z, Dong Z, Neiva K, Machado M, Shi S, Santos C, Nör JE. SHED Differentiate Into Functional Odontoblasts and Endothelium. J Dent Res 89:791-796, 2010.
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Demarco F, Casagrande L, Zhang Z, Dong Z, Tarquinio S, Zeitlin B, Shi S, Smith A, Nör JE.The effects of morphogen and scaffold porogen on the differentiation of dental pulp stem cells. J Endod36:1805-1811, 2010 (Journal cover).
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BoteroTM, SonJS, VodopyanovD, ShelburneCE, Nör JE.MAPK signaling is required for LPS-induced VEGF in pulp stem cells. J Dent Res 89:264-269, 2010 (Journal cover).
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Liu J, Jin T, Chang S, Czajka-Jakubowska A, Zhang Z, Nör JE, Clarkson BH. The effect of novel fluorapatite (FA) surfaces on osteoblast-like cell adhesion, growth and mineralization. Tissue Engineering Part A 16:2977-2986, 2010.
Personal Profile
https://medicine.umich.edu/dept/cancer-biology/jacques-nor-dds-ms-phd
https://www.dent.umich.edu/directory/jenor
https://scholar.google.com/citations?user=miXu6NkAAAAJ&hl=en&oi=sra
https://www.researchgate.net/profile/Jacques-Noer