Biography

Prof. Hung-Jen Liu

Institute of Molecular Biology
National Chung Hsing University, Chinese Taipei

Professor


Email: hjliu5257@nchu.edu.tw


Qualifications

1996 Ph.D., Auburn University, Alabama

1993 M.Sc., Auburn University, Alabama

1984 DVM, National Pingtung University of Science and Technology, Chinese Taipei


Publications (Selected)

  1. Yi-Ying Wu, Feng-Hsu Wu, I-Chun Chen, Tsai-Ling Liao, Muhammad Munir, Hung-Jen Liu*. Oncolytic avian reovirus-sensitized tumor infiltrating CD8+ T cells triggering immunogenic apoptosis in gastric cancer. Cell Communication and Signaling 22:514, 2024.
  2. Chao-Yu Hsu, Jyun-Yi Li, En-Ying Yang, Tsai-Ling Liao, Hsiao-Wei Wen, Pei-Chien Tsai, Tz-Chuen Ju, Lon-Fye Lye, Brent L. Nielsen, Hung-Jen Liu*. The oncolytic avian reovirus p17 protein inhibits invadopodia formation in murine melanoma cancer cells by suppressing the FAK/Src pathway and the formation of theTKs5/NCK1 complex. Viruses 16, 1153, 2024.
  3. Yi-Ming Chen, Kuo-Tung Tang, Hung-Jen Liu, Shih-Ting Huang, Tsai-Ling Liao. tRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle. Cell Communication and Signaling 22:354, 2024.
  4. Yu Fan Hung, Po-Chen Liu, Ching-Hung Lin, Chao-Nan Lin, Hung-Yi Wu, Ming-Tang Chiou, Hung-Jen Liu, Cheng-Yao Yang. Molecular detection of emerging porcine circovirus in Taiwan. Heliyon 10:e35579, 2024.
  5. Yu-Kang Chang, Yi-Jyum Lin, Ching-Yuan Cheng, Pei-Chien Tsai, Chi-Young Wang, Brent L. Nielsen, Hung-Jen Liu*. Nucleocytoplasmic shuttling of BEFV M protein-modulated by lamin A/C and chromosome maintenance region 1 through a transcription-, carrier-and energy-dependent pathway. Veterinary Microbiology 291:110026, 2024.
  6. Wen-Che Tsai, Yu-Shan Huang, Hsin-Yi Yin, Hung-Jen Liu, Hsiao-Wei Wen. Innovative approach for mango allergen identification in processed foods using immunomagnetic nanoparticle-enhanced UPLC-MS/MS. LWT-Food Science and Technology 204: 116446, 2024.
  7. Ching-Chou Wu, Chia-Chen Lin, Hsin-Yi Yin, Wen-Che Tsai, Ping-Feng Yang, Hung-Jen Liu, Hsiao-Wei Wen. Rapid detection of mango allergen in processed foods using an immunomagnetic nanoparticle-based electrochemical immunosensor. Microchemical Journal 198:110070, 2024.
  8. Mikael Cristofer Sitinjak, Jui-Kai Chen, Fang-Lin Liu, Ming-Hon Hou, Shan-Meng Lin, Hung-Jen Liu, Chi-Young Wang. Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV). Virus Research 349: 199458, 2024
  9. Chao-Yu Hsu, Yun Jang, Wei-Ru Huang, Chi-Young Wang, Hsiao-Wei Wen, Pei-Chien Tsai, Cheng-Yao Yang, Muhammad Muni, Hung-Jen Liu*. Development of polycistronic baculovirus surface display vectors to simultaneously express viral proteins of porcine reproductive and respiratory syndrome and analysis of their immunogenicity in swine. Vaccines 11:1666, 2023.
  10. Tsai Ling Liao, Hung Jen Liu, Der Yuan Chen, Kuo Tung Tang, Yi Ming Chen, Po Yu Liu. SARS CoV 2 primed platelets–derived microRNAs enhance NETs formation by extracellular vesicle transmission and TLR7/8 activation. Cell Communication and Signaling 21:304, 2023.
  11. Yi-Ying Wu, Te-Kai Sun, Ming-Shan Chen, Muhammad Munir, Hung-Jen Liu*. Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response. Frontiers in Cellular and Infection Microbiology13:1142172, 2023.
  12. Wei-Ru Huang, Yi-Ying Wu, Tsai-Ling Liao, Brent L. Nielsen, Hung-Jen Liu*.Cell entry of avian reovirus modulated by cell-surface annexin A2 and adhesion G protein-coupledreceptor latrophilin-2 triggers Src and p38 MAPK signaling enhancing caveolin-1- anddynamin 2-dependent endocytosis. Microbiology Spectrum 11: 3, 2023.
  13. Chao-Yu Hsu, Che-Hsueh Yang, Min-Che Tung, Hung-Jen Liu*, Yen Chuan Ou*. Robot-assisted urologic cancer surgery: current standards and future trends. Cancers , 15, 4288, 2023.
  14. Mikael Cristofer Sitinjak, Jui-Kai Chen, Meng-Yuan Lee, Hung-Jen Liu, Chi-Young Wang. Characterization of a novel reporter system for beak and feather disease virus. Gene 867: 147371, 2023.
  15. Chao-Yu Hsu, Jing-Wen Huang, Wei-Ru Huang, I-Chun Chen, Ming-Shan Chen, Tsai-Ling Liao, Yu-Kang Chang, Muhammad Munir, Hung-Jen Liu*.Oncolytic avian reovirus σA-modulated upregulation of the HIF-1α/C-myc/glut1 pathway to produce more energy in different cancer cell lines benefiting virus replication. Viruses 15:523, 2023.
  16. Jyun-Yi Li, Wei‐Ru Huang, Tsai-Ling Liao, Brent L. Nielsen, Hung-Jen Liu*. Oncolytic avian reovirus p17-modulated inhibition of mTORC1 by enhancement of the endogenous mTORC1 inhibitors binding to mTORC1 to disrupt its assembly and accumulation on lysosomes. Journal of Virology 96(17):e0083622, 2022.
  17. Wei‐Ru Huang, Jyun-Yi Li, Yi-Ying Wu, Tsai-Ling Liao, Brent L. Nielsen, Hung-Jen Liu*. p17-modulated Hsp90/Cdc37 complex governs avian reovirus replication by chaperoning p17 that promotes viral protein synthesis and accumulation of proteins σA and σC in viral factories. Journal of Virology 96(2):e00074-22, 2022.
  18. Chao-Yu Hsu, Yun-Han Chen, Wei‐Ru Huang, Jing-Wen Huang, I-Chun Chen, Yu-Kang Chang, Chi-Young Wang, Ching-Dong Chang, Tsai-Ling Liao, Brent L. Nielsen, Hung-Jen Liu*.Oncolytic avian reovirus σA-modulated fatty acid metabolism through the PSMB6/Akt/SREBP1/acetyl-CoA carboxylase pathway to increase energy production for virus replication. Veterinary Microbiology 273:109545, 2022.
  19. Chao-Yu Hsu, Chung-Yiu Hsieh, Cheng-Yao Yang, Yu-Kang Chang, Wen-Ling Shih, Chuan-Ming Yeh, Nien-Jen Hu, Ming-Shan Chen, Brent L. Nielsen, Hung-Jen Liu*.Sortase A fusion expression and mIFc2 co-expression of bovine lactoferricin and analysis of its antibacterial activity. Processes 10: 2470, 2022.
  20. Yi-Ming Chen, Po-Yu Liu, Kuo-Tung Tang, Hung-Jen Liu,Tsai-Ling Liao.TWEAK-Fn14 axis induces calcium-associated autophagy and cell death to control Mycobacterial survival in macrophages. Microbiology Spectrum 10(6):e0317222, 2022.
  21. Wei‐Ru Huang, Jyun-Yi Li, Tsai-Ling Liao, Chuan-Ming Yeh, Chao-Yu Hsu, Yu-Kang Chang, Ching-Dong Chang, Brent L. Nielsen, Hung-Jen Liu*. Molecular chaperone TRiC governs avian reovirus replication by preventing outer-capsid protein σC and core protein σA and non-structural protein σNS from ubiquitin-proteasome degradation. Veterinary Microbiology 264: 109277, 2022.
  22. Fang-Lin Liu, Shu-Ping Chang, Hung-Jen Liu, Pan-Chen Liu, Chi-Young Wang. Genomic and phylogenetic analysis of avian polyomavirus Taiwan isolates. Virus Research 308:196834, 2022.
  23. Tsai-Ling Liao, Yi-Ming Chen, Shie-Liang Hsieh, Kuo-Tung Tang, Der-Yuan Chen, Ying-Ying Yang, Hung-Jen Liu, Sheng-Shun Yang. Hepatitis C virus-induced exosomal microRNAs and TLR7 polymorphism regulate B-cell activating factor. mBio 12(6): e02764-21, 2021.
  24. Tsai Ling Liao, Yi Ming Chen, Kuo TungTang, Po Ku Chen, Hung Jen Liu, Der Yuan Chen. MicroRNA 223 inhibits neutrophil extracellular traps formation through regulating calcium infux and Small extracellular vesicles transmission. Scientific Report 11:15676, 2021.
  25. Wen-Che Tsai, Hsin-Yi Yin, Ya-Ting Lin, Hung-Jen Liu, Chang-Yen Tseng, Hsiao-Wei Wen. A rapid lateral flow assay using immunomagnetic nanoparticles for detecting mango allergen residues in processed foods. Journal of Food Safety e: 12929, 2021.
  26. Chen IC, Kuo PH, Yang AC, Tsai SJ, Liu TH, Liu HJ*, Lan TH, Chen HM, Huang HN, Chung RH, Liu YL*. CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. Scientific Report 10: 18118, 2020.
  27. Tseng HH, Huang WR, Cheng CY, Chiu HC, Liao TL, Nielsen BL, Liu HJ*. Aspirin and 5-aminoimidazole-4-carboxamide riboside attenuate bovine ephemeral fever virus replication by inhibiting BEFV-induced autophagy. Frontier in Immunology 11: 556838, 2020.
  28. Chen YY, Yang WC, Chang YK, Wang CY, Huang WR, Li JY, Wu HY, Chang CD, Nielsen BL, Liu HJ*. Construction of polycistronic baculovirus surface display vectors to express the PCV2 Cap(d41) protein and its immunogenicity of the expressed proteins in mice and swine. Veterinary Research 51:112, 2020.
  29. Santos HＭ, Tsai CY, Catulin GEM, Trangia KCG, Tayo LL, Liu HJ, Chuang KP. Common bacterial, viral and parasitic diseases in pigeons (Columba livia): A review of diagnostic and treatment strategies. Veterinary Microbiol. 247:108779, 2020.
  30. Tung MC, Lu HY, Chang YK, Huang WR, Liao TL, Wu HY, Chang CD, Nielsen BL, Liu HJ*. Baculovirus surface display of the HA protein of H5N2 avian influenza virus and its immunogenicity against a lethal challenge with H5N1 virus in chickens. Veterinary Microbiology 243, 108640, 2020.
  31. Chen DY, Chen YM, Lin CF, Lo CM, Liu HJ, Liao TL. MicroRNA-889 inhibits autophagy to maintain mycobacterial survival in patients with latent tuberculosis infection by targeting TWEAK. mBio 11(1), e03045-19, 2020.
  32. Chen IC, Teng G, Chen CJ, Lan TH, Liu HJ*. The autonomic progress bar motivates treatment completion for patients of stimulant use disorder and cannabis use disorder. Frontiers in Psychiatry 10, 944, 2020.
  33. Chiu HC, Huang WR, Wang YY, Li JY, Liao TL, Nielsen B, Liu HJ*. Heterogeneous Nuclear ribonucleoprotein A1 and lamin A/C modulate nucleocytoplasmic shuttling of avian reovirus p17. Journal of Virology 93(20): 00851-19, 2019.
  34. Ching-Yuan Cheng, Hsu-Hung Tseng, Hung-Chuan Chiu, Ching-Dong Chang, Brent L. Nielsen, Hung-Jen Liu*. Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway. Veterinary Research 50: 79, 2019.
  35. Wang Q, Huang WR, Chih WY, Chuang KP, Chang CD, Wu Y, Huang Y, Liu HJ*. Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis. Veterinary Microbiology 235:151-163, 2019.
  36. Quanxi Wang, Mengxi Liu, Yuan Chen, Lihui Xu, Baocheng Wu, Yijan Wu, Yifan Huang, Wei-Ru Huang, Hung-Jen Liu*. Muscovy duck reovirus p10.8 protein induces ER stress and apoptosis through the Bip/IRE1/XBP1 pathway. Veterinary Microbiology 228: 234-245, 2019.


Profile Details

https://www.nchu.edu.tw/~mbio/wb_main_faculty17.html

https://www.researchgate.net/profile/Hung-Jen-Liu

https://orcid.org/0000-0002-1460-1494


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